Cargando…

Genetically engineered pre-microRNA-34a prodrug suppresses orthotopic osteosarcoma xenograft tumor growth via the induction of apoptosis and cell cycle arrest

Osteosarcoma (OS) is the most common primary malignant bone tumor in children, and microRNA-34a (miR-34a) replacement therapy represents a new treatment strategy. This study was to define the effectiveness and safety profiles of a novel bioengineered miR-34a prodrug in orthotopic OS xenograft tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Yong, Tu, Mei-Juan, Wang, Wei-Peng, Qiu, Jing-Xin, Yu, Ai-Xi, Yu, Ai-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877571/ https://www.ncbi.nlm.nih.gov/pubmed/27216562 http://dx.doi.org/10.1038/srep26611

Ejemplares similares

A genetically engineered microRNA-34a prodrug demonstrates anti-tumor activity in a canine model of osteosarcoma
por: Alegre, Fernando, et al.
Publicado: (2018)

Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models
por: da Costa, Maria Eugenia Marques, et al.
Publicado: (2023)

Clinically relevant orthotopic xenograft models of patient-derived glioblastoma in zebrafish
por: Ai, Xiaolin, et al.
Publicado: (2022)

Evaluation of intraarterial and intravenous cisplatin chemotherapy in the treatment of metastatic osteosarcoma using an orthotopic xenograft mouse model
por: Robl, Bernhard, et al.
Publicado: (2016)

The Optimal Outcome of Suppressing Ewing Sarcoma Growth in vivo With Biocompatible Bioengineered miR-34a-5p Prodrug
por: Li, Dai-Feng, et al.
Publicado: (2020)

Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG-63 cells and xenograft mice models via inhibition of cell migration and invasion, cell cycle arrest and induction of mitochondrial-mediated apoptosis
por: Du, Guang-Yu, et al.
Publicado: (2018)

[Retracted] Hesperidin exhibits in vitro and in vivo antitumor effects in human osteosarcoma MG‑63 cells and xenograft mice models via inhibition of cell migration and invasion, cell cycle arrest and induction of mitochondrial‑mediated apoptosis
por: Du, Guang-Yu, et al.
Publicado: (2023)

Establishment and characterization of in vivo orthotopic bioluminescent xenograft models from human osteosarcoma cell lines in Swiss nude and NSG mice
por: Marques da Costa, Maria Eugenia, et al.
Publicado: (2018)

The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model
por: Higuchi, Takashi, et al.
Publicado: (2019)

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
por: Jäger, Wolfgang, et al.
Publicado: (2014)

Development and characterization of a human orthotopic neuroblastoma xenograft
por: Stewart, Elizabeth, et al.
Publicado: (2015)

Orthotopic Patient-Derived Xenografts of Pediatric Solid Tumors
por: Stewart, Elizabeth, et al.
Publicado: (2017)

Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma †
por: Hoffman, Robert M.
Publicado: (2017)

Orthotopic tumours, a hot topic for xenograft models?
por: Zheng, Dali
Publicado: (2019)

Establishment of an orthotopic perirenal space xenograft mouse model of retroperitoneal sarcoma
por: Xie, Fu'an, et al.
Publicado: (2021)

Engineering Prodrug Nanomedicine for Cancer Immunotherapy
por: Yang, Bin, et al.
Publicado: (2020)

The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts
por: Fung, Andrea S, et al.
Publicado: (2015)

Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model
por: Kiyuna, Tasuku, et al.
Publicado: (2018)

Intravesical administration of exogenous microRNA-145 as a therapy for mouse orthotopic human bladder cancer xenograft
por: Inamoto, Teruo, et al.
Publicado: (2015)

An orthotopic xenograft model of human nonseminomatous germ cell tumour
por: Douglas, M L, et al.
Publicado: (2001)

Dynamic Quantitative T1 Mapping in Orthotopic Brain Tumor Xenografts()
por: Herrmann, Kelsey, et al.
Publicado: (2016)

1,3,5-triazines inhibit osteosarcoma and avert lung metastasis in a patient-derived orthotopic xenograft mouse model with favorable pharmacokinetics
por: Su, Qing, et al.
Publicado: (2022)

Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer Cells
por: Xie, Wei, et al.
Publicado: (2017)

INSP-09. Using genetically engineered mouse models and patient-derived orthotopic xenografts to develop new therapies for pediatric brain tumors.
por: Jonchere, Barbara, et al.
Publicado: (2022)

Temozolomide combined with irinotecan regresses a cisplatinum-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) precision-oncology mouse model
por: Igarashi, Kentaro, et al.
Publicado: (2017)

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor
por: Sicklick, Jason K, et al.
Publicado: (2014)

Multimodality Imaging Methods for Assessing Retinoblastoma Orthotopic Xenograft Growth and Development
por: Corson, Timothy W., et al.
Publicado: (2014)

Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts
por: Koessinger, Anna L., et al.
Publicado: (2020)

Eribulin prolongs survival in an orthotopic xenograft mouse model of malignant meningioma
por: Nakano, Tomoyuki, et al.
Publicado: (2021)

Establishment of a patient-derived orthotopic osteosarcoma mouse model
por: Blattmann, Claudia, et al.
Publicado: (2015)

Daphnoretin Induces Cell Cycle Arrest and Apoptosis in Human Osteosarcoma (HOS) Cells
por: Gu, Shoubin, et al.
Publicado: (2012)

The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.
por: Houba, P. H., et al.
Publicado: (1998)

Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
por: Lohse, Ines, et al.
Publicado: (2016)

Bioengineered miR-124-3p prodrug selectively alters the proteome of human carcinoma cells to control multiple cellular components and lung metastasis in vivo
por: Deng, Linglong, et al.
Publicado: (2021)

Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model
por: Mazumdar, Alekhya, et al.
Publicado: (2020)

A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology
por: Igarashi, Kentaro, et al.
Publicado: (2017)

Orthotopic xenografts of human melanoma and colonic and ovarian carcinoma in sheep to evaluate radioimmunotherapy.
por: Turner, J. H., et al.
Publicado: (1998)

Dasatinib enhances tumor growth in gemcitabine-resistant orthotopic bladder cancer xenografts
por: Vallo, Stefan, et al.
Publicado: (2016)

Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts
por: Chaudary, Naz, et al.
Publicado: (2017)

Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy
por: Patrizii, Michele, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tgkv37ulqrunjal36b2q0n4kr3