MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors

Aberrant expression of myeloid cell leukemia-1 (MCL-1) is a major cause of drug resistance in triple-negative breast cancer (TNBC) cells. Mucin 1 (MUC1) is a heterodimeric oncoprotein that is aberrantly overexpressed in most TNBC. The present studies show that targeting the oncogenic MUC1 C-terminal...

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Detalles Bibliográficos
Autores principales: Hiraki, Masayuki, Suzuki, Yozo, Alam, Maroof, Hinohara, Kunihiko, Hasegawa, Masanori, Jin, Caining, Kharbanda, Surender, Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877578/
https://www.ncbi.nlm.nih.gov/pubmed/27217294
http://dx.doi.org/10.1038/srep26643

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