Cargando…

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinomas (cSCC) are the most common and highly mutated human malignancies, challenging identification of driver mutations and targeted therapies. Transcription factor NF-E2 p45-related factor 2 (Nrf2) orchestrates a cytoprotective inducible program, which counteracts the da...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knatko, Elena V., Higgins, Maureen, Fahey, Jed W., Dinkova-Kostova, Albena T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877584/ https://www.ncbi.nlm.nih.gov/pubmed/27216826 http://dx.doi.org/10.1038/srep25804

Ejemplares similares

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2021)

Downregulation of Keap1 Confers Features of a Fasted Metabolic State
por: Knatko, Elena V., et al.
Publicado: (2020)

The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
por: Dinkova-Kostova, Albena T.
Publicado: (2012)

Monitoring Keap1–Nrf2 interactions in single live cells
por: Baird, Liam, et al.
Publicado: (2014)

Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma
por: Roth, Kevin, et al.
Publicado: (2021)

Pirin, an Nrf2-Regulated Protein, Is Overexpressed in Human Colorectal Tumors
por: Zhang, Ying, et al.
Publicado: (2022)

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2015)

Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2018)

Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer
por: Knatko, Elena V., et al.
Publicado: (2021)

NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
por: Kahremany, Shirin, et al.
Publicado: (2022)

Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants()
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2020)

Phenyl Bis-Sulfonamide Keap1-Nrf2 Protein–Protein Interaction Inhibitors with an Alternative Binding Mode
por: Georgakopoulos, Nikolaos, et al.
Publicado: (2022)

The emerging role of Nrf2 in mitochondrial function
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2015)

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
por: Horie, Yuta, et al.
Publicado: (2021)

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?
por: Yagishita, Yoko, et al.
Publicado: (2019)

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2018)

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model
por: Kalin, Jay H., et al.
Publicado: (2019)

The multifaceted role of Nrf2 in mitochondrial function
por: Holmström, Kira M., et al.
Publicado: (2016)

The role of Nrf2 signaling in counteracting neurodegenerative diseases
por: Dinkova‐Kostova, Albena T., et al.
Publicado: (2018)

Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2022)

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
por: Robertson, Holly, et al.
Publicado: (2020)

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action
por: Kostov, Rumen V., et al.
Publicado: (2015)

Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment
por: Feng, Jialin, et al.
Publicado: (2023)

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production
por: Cvetko, Filip, et al.
Publicado: (2020)

NRF2 as an Emerging Therapeutic Target
por: Copple, Ian M., et al.
Publicado: (2017)

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity
por: Casares, Laura, et al.
Publicado: (2020)

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner
por: Zhang, Ying, et al.
Publicado: (2021)

Transcription factors NRF2 and HSF1 have opposing functions in autophagy
por: Dayalan Naidu, Sharadha, et al.
Publicado: (2017)

Nrf2 regulates ROS production by mitochondria and NADPH oxidase
por: Kovac, Stjepana, et al.
Publicado: (2015)

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells
por: Roubalová, Lenka, et al.
Publicado: (2017)

Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder
por: Liu, Hua, et al.
Publicado: (2020)

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity
por: Olagnier, David, et al.
Publicado: (2017)

Radiomodulatory effect of a non-electrophilic NQO1 inducer identified in a screen of new 6, 8-diiodoquinazolin-4(3H)-ones carrying a sulfonamide moiety
por: Soliman, Aiten M., et al.
Publicado: (2020)

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells
por: Roubalová, Lenka, et al.
Publicado: (2016)

Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
por: Ryan, Dylan G., et al.
Publicado: (2022)

The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage
por: Amirova, Kristiana M., et al.
Publicado: (2023)

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives
por: Ghorab, Mostafa M, et al.
Publicado: (2016)

Nrf2 regulates glucose uptake and metabolism in neurons and astrocytes
por: Esteras, Noemí, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qtlbhothe54iecstisiflkm6tn