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Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinomas (cSCC) are the most common and highly mutated human malignancies, challenging identification of driver mutations and targeted therapies. Transcription factor NF-E2 p45-related factor 2 (Nrf2) orchestrates a cytoprotective inducible program, which counteracts the da...

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Detalles Bibliográficos
Autores principales:	Knatko, Elena V., Higgins, Maureen, Fahey, Jed W., Dinkova-Kostova, Albena T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877584/ https://www.ncbi.nlm.nih.gov/pubmed/27216826 http://dx.doi.org/10.1038/srep25804

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