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Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis

Doxorubicin (Dox), one of the most effective chemotherapy drug for cancer treatment, is limited by its severe side effects and chemoresistance. Dox induces DNA damage and leads to significant proteomic changes in the cancer cells, which makes the ubiquitin-proteasome system a potential target to enh...

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Detalles Bibliográficos
Autores principales:	Wang, Hao, Yu, Yang, Jiang, Zheng, Cao, Wen-Ming, Wang, Zhenyu, Dou, Jun, Zhao, Yanling, Cui, Yunfu, Zhang, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877646/ https://www.ncbi.nlm.nih.gov/pubmed/27217076 http://dx.doi.org/10.1038/srep26456

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