A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells

The implementation of the Syrian hamster embryo cell transformation assay (SHE CTA) into test batteries and its relevance in predicting carcinogenicity has been long debated. Despite prevalidation studies to ensure reproducibility and minimise the subjective nature of the assay’s endpoint, an underl...

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Detalles Bibliográficos
Autores principales: Pickles, Jessica C., Pant, Kamala, Mcginty, Lisa A., Yasaei, Hemad, Roberts, Terry, Scott, Andrew D., Newbold, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877681/
https://www.ncbi.nlm.nih.gov/pubmed/27169376
http://dx.doi.org/10.1016/j.mrgentox.2016.04.002

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