Tyrosine 625 plays a key role and cooperates with tyrosine 630 in MPL W515L-induced signaling and myeloproliferative neoplasms

BACKGROUND: Myeloproliferative neoplasms (MPN) are a group of blood cancers that boost normal blood cell production in the bone marrow. Abnormal mutations in stem cells were found accompanying with the occurrence of MPN. It has been shown that MPL mutations (MPL W515L or MPL W515K) were involved in...

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Detalles Bibliográficos
Autores principales: Yu, Chunjie, Yang, Qiong, Chen, Yuhong, Wang, Demin, Levine, Ross, Crispino, John, Wen, Qiang, Huang, Zan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877759/
https://www.ncbi.nlm.nih.gov/pubmed/27222706
http://dx.doi.org/10.1186/s13578-016-0097-3

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