Statistical Study of Risk Factors of End Stage Renal Failure in Peshawar, Pakistan

BACKGROUND: End Stage Renal Failure (ESRD) is the last stage of the chronic renal failure in which kidneys become completely fail to function. AIM: The basic aim of this study was to discover the important risk factors of ESRD and to construct a model for prediction of the ESRD patients in various hospitals of Peshawar, Pakistan. MATERIAL AND METHODS: The data were collected from the patients of renal diseases from three major hospitals of Peshawar. Brown method was used to obtain initial model, then backward elimination logistic regression analysis was performed to find the significant variables (risk factors). The response variable (ESRD) in this study is binary; therefore, logistic regression analysis is used to identify the significant variables. A Statistical Package GLIM and SPSS were used for fitting the model and for finding the significant variables. RESULTS: The backward elimination procedure selects predictor variables diabetic, hypertension, glomerulonephritis and heredity, for males. Thus, these variables are the main causes of ESRD. For females, the predictor variables selected are hypertension & (Diabetic*Hypertension), which means that hypertension and hypertensive diabetic are significant causes of ESRD. CONCLUSION: Our main conclusion from this analysis is that diabetic, hypertension and glomerulonephritis are the significant risk factors of ESRD.