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Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin

AIM: To evaluate cardiac affection in type 1 diabetes in relation to Omentin. PATIENTS AND METHODS: Sixty two diabetics and 30 volunteer of the same age and sex were included as a control group. Blood sample was taken for assessment of omentin and oxidized low density lipoprotein (OxLDL), glycosylat...

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Autores principales: Dayem, Soha M. Abd El, Battah, Ahmed A., Shehaby, Amal El
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institute of Immunobiology and Human Genetics 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877911/
https://www.ncbi.nlm.nih.gov/pubmed/27275311
http://dx.doi.org/10.3889/oamjms.2015.132
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author Dayem, Soha M. Abd El
Battah, Ahmed A.
Shehaby, Amal El
author_facet Dayem, Soha M. Abd El
Battah, Ahmed A.
Shehaby, Amal El
author_sort Dayem, Soha M. Abd El
collection PubMed
description AIM: To evaluate cardiac affection in type 1 diabetes in relation to Omentin. PATIENTS AND METHODS: Sixty two diabetics and 30 volunteer of the same age and sex were included as a control group. Blood sample was taken for assessment of omentin and oxidized low density lipoprotein (OxLDL), glycosylated hemoglobin (HbA1) and lipid profile. Urine sample was taken for assessment of albumin/creatinine ratio. 24 hour holter was also done. T-test, simple correlation followed by stepwise multiple regression analysis was used for analysis of data. RESULTS: Parameters of 24 hour holter were significantly lower in diabetics. Omentin was significantly lower, while OxLDL were significantly higher than controls. RMSSD, ST deviation and OxLDL were the parameters related to omentin by stepwise multiple regression analysis in diabetics. CONCLUSION: Diabetic patients had a cardiac autonomic neuropathy. A significant reduction of omentin and elevation OxLDL imply that they influence glucose metabolism in type 1 diabetes. Omentin had a significant relation to 24 hr holter which may reflect its role in cardiac affection. Omentin and OxLDL had a role in renal affection.
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spelling pubmed-48779112016-06-06 Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin Dayem, Soha M. Abd El Battah, Ahmed A. Shehaby, Amal El Open Access Maced J Med Sci Clinical Science AIM: To evaluate cardiac affection in type 1 diabetes in relation to Omentin. PATIENTS AND METHODS: Sixty two diabetics and 30 volunteer of the same age and sex were included as a control group. Blood sample was taken for assessment of omentin and oxidized low density lipoprotein (OxLDL), glycosylated hemoglobin (HbA1) and lipid profile. Urine sample was taken for assessment of albumin/creatinine ratio. 24 hour holter was also done. T-test, simple correlation followed by stepwise multiple regression analysis was used for analysis of data. RESULTS: Parameters of 24 hour holter were significantly lower in diabetics. Omentin was significantly lower, while OxLDL were significantly higher than controls. RMSSD, ST deviation and OxLDL were the parameters related to omentin by stepwise multiple regression analysis in diabetics. CONCLUSION: Diabetic patients had a cardiac autonomic neuropathy. A significant reduction of omentin and elevation OxLDL imply that they influence glucose metabolism in type 1 diabetes. Omentin had a significant relation to 24 hr holter which may reflect its role in cardiac affection. Omentin and OxLDL had a role in renal affection. Institute of Immunobiology and Human Genetics 2015-12-15 2015-12-13 /pmc/articles/PMC4877911/ /pubmed/27275311 http://dx.doi.org/10.3889/oamjms.2015.132 Text en Copyright: © 2015 Soha M. Abd El Dayem, Ahmed A. Battah, Amal El Shehaby. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Science
Dayem, Soha M. Abd El
Battah, Ahmed A.
Shehaby, Amal El
Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin
title Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin
title_full Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin
title_fullStr Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin
title_full_unstemmed Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin
title_short Cardiac Affection in Type 1 Diabetic Patients in Relation to Omentin
title_sort cardiac affection in type 1 diabetic patients in relation to omentin
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877911/
https://www.ncbi.nlm.nih.gov/pubmed/27275311
http://dx.doi.org/10.3889/oamjms.2015.132
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