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DSCR1 is required for both axonal growth cone extension and steering
Local information processing in the growth cone is essential for correct wiring of the nervous system. As an axon navigates through the developing nervous system, the growth cone responds to extrinsic guidance cues by coordinating axon outgrowth with growth cone steering. It has become increasingly...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878092/ https://www.ncbi.nlm.nih.gov/pubmed/27185837 http://dx.doi.org/10.1083/jcb.201510107 |
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author | Wang, Wei Rai, Asit Hur, Eun-Mi Smilansky, Zeev Chang, Karen T. Min, Kyung-Tai |
author_facet | Wang, Wei Rai, Asit Hur, Eun-Mi Smilansky, Zeev Chang, Karen T. Min, Kyung-Tai |
author_sort | Wang, Wei |
collection | PubMed |
description | Local information processing in the growth cone is essential for correct wiring of the nervous system. As an axon navigates through the developing nervous system, the growth cone responds to extrinsic guidance cues by coordinating axon outgrowth with growth cone steering. It has become increasingly clear that axon extension requires proper actin polymerization dynamics, whereas growth cone steering involves local protein synthesis. However, molecular components integrating these two processes have not been identified. Here, we show that Down syndrome critical region 1 protein (DSCR1) controls axon outgrowth by modulating growth cone actin dynamics through regulation of cofilin activity (phospho/dephospho-cofilin). Additionally, DSCR1 mediates brain-derived neurotrophic factor–induced local protein synthesis and growth cone turning. Our study identifies DSCR1 as a key protein that couples axon growth and pathfinding by dually regulating actin dynamics and local protein synthesis. |
format | Online Article Text |
id | pubmed-4878092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48780922016-11-23 DSCR1 is required for both axonal growth cone extension and steering Wang, Wei Rai, Asit Hur, Eun-Mi Smilansky, Zeev Chang, Karen T. Min, Kyung-Tai J Cell Biol Research Articles Local information processing in the growth cone is essential for correct wiring of the nervous system. As an axon navigates through the developing nervous system, the growth cone responds to extrinsic guidance cues by coordinating axon outgrowth with growth cone steering. It has become increasingly clear that axon extension requires proper actin polymerization dynamics, whereas growth cone steering involves local protein synthesis. However, molecular components integrating these two processes have not been identified. Here, we show that Down syndrome critical region 1 protein (DSCR1) controls axon outgrowth by modulating growth cone actin dynamics through regulation of cofilin activity (phospho/dephospho-cofilin). Additionally, DSCR1 mediates brain-derived neurotrophic factor–induced local protein synthesis and growth cone turning. Our study identifies DSCR1 as a key protein that couples axon growth and pathfinding by dually regulating actin dynamics and local protein synthesis. The Rockefeller University Press 2016-05-23 /pmc/articles/PMC4878092/ /pubmed/27185837 http://dx.doi.org/10.1083/jcb.201510107 Text en © 2016 Wang et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Research Articles Wang, Wei Rai, Asit Hur, Eun-Mi Smilansky, Zeev Chang, Karen T. Min, Kyung-Tai DSCR1 is required for both axonal growth cone extension and steering |
title | DSCR1 is required for both axonal growth cone extension and steering |
title_full | DSCR1 is required for both axonal growth cone extension and steering |
title_fullStr | DSCR1 is required for both axonal growth cone extension and steering |
title_full_unstemmed | DSCR1 is required for both axonal growth cone extension and steering |
title_short | DSCR1 is required for both axonal growth cone extension and steering |
title_sort | dscr1 is required for both axonal growth cone extension and steering |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878092/ https://www.ncbi.nlm.nih.gov/pubmed/27185837 http://dx.doi.org/10.1083/jcb.201510107 |
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