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The Geobacillus Pan-Genome: Implications for the Evolution of the Genus
The genus Geobacillus is comprised of a diverse group of spore-forming Gram-positive thermophilic bacterial species and is well known for both its ecological diversity and as a source of novel thermostable enzymes. Although the mechanisms underlying the thermophilicity of the organism and the thermo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878294/ https://www.ncbi.nlm.nih.gov/pubmed/27252683 http://dx.doi.org/10.3389/fmicb.2016.00723 |
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author | Bezuidt, Oliver K. Pierneef, Rian Gomri, Amin M. Adesioye, Fiyin Makhalanyane, Thulani P. Kharroub, Karima Cowan, Don A. |
author_facet | Bezuidt, Oliver K. Pierneef, Rian Gomri, Amin M. Adesioye, Fiyin Makhalanyane, Thulani P. Kharroub, Karima Cowan, Don A. |
author_sort | Bezuidt, Oliver K. |
collection | PubMed |
description | The genus Geobacillus is comprised of a diverse group of spore-forming Gram-positive thermophilic bacterial species and is well known for both its ecological diversity and as a source of novel thermostable enzymes. Although the mechanisms underlying the thermophilicity of the organism and the thermostability of its macromolecules are reasonably well understood, relatively little is known of the evolutionary mechanisms, which underlie the structural and functional properties of members of this genus. In this study, we have compared 29 Geobacillus genomes, with a specific focus on the elements, which comprise the conserved core and flexible genomes. Based on comparisons of conserved core and flexible genomes, we present evidence of habitat delineation with specific Geobacillus genomes linked to specific niches. Our analysis revealed that Geobacillus and Anoxybacillus share a high proportion of genes. Moreover, the results strongly suggest that horizontal gene transfer is a major factor deriving the evolution of Geobacillus from Bacillus, with genetic contributions from other phylogenetically distant taxa. |
format | Online Article Text |
id | pubmed-4878294 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48782942016-06-01 The Geobacillus Pan-Genome: Implications for the Evolution of the Genus Bezuidt, Oliver K. Pierneef, Rian Gomri, Amin M. Adesioye, Fiyin Makhalanyane, Thulani P. Kharroub, Karima Cowan, Don A. Front Microbiol Microbiology The genus Geobacillus is comprised of a diverse group of spore-forming Gram-positive thermophilic bacterial species and is well known for both its ecological diversity and as a source of novel thermostable enzymes. Although the mechanisms underlying the thermophilicity of the organism and the thermostability of its macromolecules are reasonably well understood, relatively little is known of the evolutionary mechanisms, which underlie the structural and functional properties of members of this genus. In this study, we have compared 29 Geobacillus genomes, with a specific focus on the elements, which comprise the conserved core and flexible genomes. Based on comparisons of conserved core and flexible genomes, we present evidence of habitat delineation with specific Geobacillus genomes linked to specific niches. Our analysis revealed that Geobacillus and Anoxybacillus share a high proportion of genes. Moreover, the results strongly suggest that horizontal gene transfer is a major factor deriving the evolution of Geobacillus from Bacillus, with genetic contributions from other phylogenetically distant taxa. Frontiers Media S.A. 2016-05-24 /pmc/articles/PMC4878294/ /pubmed/27252683 http://dx.doi.org/10.3389/fmicb.2016.00723 Text en Copyright © 2016 Bezuidt, Pierneef, Gomri, Adesioye, Makhalanyane, Kharroub and Cowan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Bezuidt, Oliver K. Pierneef, Rian Gomri, Amin M. Adesioye, Fiyin Makhalanyane, Thulani P. Kharroub, Karima Cowan, Don A. The Geobacillus Pan-Genome: Implications for the Evolution of the Genus |
title | The Geobacillus Pan-Genome: Implications for the Evolution of the Genus |
title_full | The Geobacillus Pan-Genome: Implications for the Evolution of the Genus |
title_fullStr | The Geobacillus Pan-Genome: Implications for the Evolution of the Genus |
title_full_unstemmed | The Geobacillus Pan-Genome: Implications for the Evolution of the Genus |
title_short | The Geobacillus Pan-Genome: Implications for the Evolution of the Genus |
title_sort | geobacillus pan-genome: implications for the evolution of the genus |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878294/ https://www.ncbi.nlm.nih.gov/pubmed/27252683 http://dx.doi.org/10.3389/fmicb.2016.00723 |
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