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MTRNR2L12: A Candidate Blood Marker of Early Alzheimer’s Disease-Like Dementia in Adults with Down Syndrome
Morphological abnormalities observed typically in the brains of adults with Down syndrome are identical with those present in patients with Alzheimer’s disease. However, only some adults with Down syndrome suffer from early dementia, whereas others remain unaffected. We aimed to identify the genomic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878308/ https://www.ncbi.nlm.nih.gov/pubmed/25720405 http://dx.doi.org/10.3233/JAD-143030 |
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author | Bik-Multanowski, Miroslaw Pietrzyk, Jacek J. Midro, Alina |
author_facet | Bik-Multanowski, Miroslaw Pietrzyk, Jacek J. Midro, Alina |
author_sort | Bik-Multanowski, Miroslaw |
collection | PubMed |
description | Morphological abnormalities observed typically in the brains of adults with Down syndrome are identical with those present in patients with Alzheimer’s disease. However, only some adults with Down syndrome suffer from early dementia, whereas others remain unaffected. We aimed to identify the genomic background responsible for this observation. We performed cognitive assessment and genome expression analysis of blood mononuclear cells in seniors with Down syndrome. Unaffected elderly patients and younger patients with severe cognitive disability or cognitive deterioration differed significantly with regard to the MTRNR2L12 gene. Our findings suggest the potential value of this gene as a blood marker of early dementia in individuals with Down syndrome. |
format | Online Article Text |
id | pubmed-4878308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48783082016-06-09 MTRNR2L12: A Candidate Blood Marker of Early Alzheimer’s Disease-Like Dementia in Adults with Down Syndrome Bik-Multanowski, Miroslaw Pietrzyk, Jacek J. Midro, Alina J Alzheimers Dis Research Article Morphological abnormalities observed typically in the brains of adults with Down syndrome are identical with those present in patients with Alzheimer’s disease. However, only some adults with Down syndrome suffer from early dementia, whereas others remain unaffected. We aimed to identify the genomic background responsible for this observation. We performed cognitive assessment and genome expression analysis of blood mononuclear cells in seniors with Down syndrome. Unaffected elderly patients and younger patients with severe cognitive disability or cognitive deterioration differed significantly with regard to the MTRNR2L12 gene. Our findings suggest the potential value of this gene as a blood marker of early dementia in individuals with Down syndrome. IOS Press 2015-05-07 /pmc/articles/PMC4878308/ /pubmed/25720405 http://dx.doi.org/10.3233/JAD-143030 Text en IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License. |
spellingShingle | Research Article Bik-Multanowski, Miroslaw Pietrzyk, Jacek J. Midro, Alina MTRNR2L12: A Candidate Blood Marker of Early Alzheimer’s Disease-Like Dementia in Adults with Down Syndrome |
title | MTRNR2L12: A Candidate Blood Marker of Early Alzheimer’s Disease-Like Dementia in Adults with Down Syndrome |
title_full | MTRNR2L12: A Candidate Blood Marker of Early Alzheimer’s Disease-Like Dementia in Adults with Down Syndrome |
title_fullStr | MTRNR2L12: A Candidate Blood Marker of Early Alzheimer’s Disease-Like Dementia in Adults with Down Syndrome |
title_full_unstemmed | MTRNR2L12: A Candidate Blood Marker of Early Alzheimer’s Disease-Like Dementia in Adults with Down Syndrome |
title_short | MTRNR2L12: A Candidate Blood Marker of Early Alzheimer’s Disease-Like Dementia in Adults with Down Syndrome |
title_sort | mtrnr2l12: a candidate blood marker of early alzheimer’s disease-like dementia in adults with down syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878308/ https://www.ncbi.nlm.nih.gov/pubmed/25720405 http://dx.doi.org/10.3233/JAD-143030 |
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