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Calmodulin Binding Proteins and Alzheimer’s Disease
The small, calcium-sensor protein, calmodulin, is ubiquitously expressed and central to cell function in all cell types. Here the literature linking calmodulin to Alzheimer’s disease is reviewed. Several experimentally-verified calmodulin-binding proteins are involved in the formation of amyloid-β p...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878311/ https://www.ncbi.nlm.nih.gov/pubmed/25812852 http://dx.doi.org/10.3233/JAD-142772 |
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author | O’Day, Danton H. Eshak, Kristeen Myre, Michael A. |
author_facet | O’Day, Danton H. Eshak, Kristeen Myre, Michael A. |
author_sort | O’Day, Danton H. |
collection | PubMed |
description | The small, calcium-sensor protein, calmodulin, is ubiquitously expressed and central to cell function in all cell types. Here the literature linking calmodulin to Alzheimer’s disease is reviewed. Several experimentally-verified calmodulin-binding proteins are involved in the formation of amyloid-β plaques including amyloid-β protein precursor, β-secretase, presenilin-1, and ADAM10. Many others possess potential calmodulin-binding domains that remain to be verified. Three calmodulin binding proteins are associated with the formation of neurofibrillary tangles: two kinases (CaMKII, CDK5) and one protein phosphatase (PP2B or calcineurin). Many of the genes recently identified by genome wide association studies and other studies encode proteins that contain putative calmodulin-binding domains but only a couple (e.g., APOE, BIN1) have been experimentally confirmed as calmodulin binding proteins. At least two receptors involved in calcium metabolism and linked to Alzheimer’s disease (mAchR; NMDAR) have also been identified as calmodulin-binding proteins. In addition to this, many proteins that are involved in other cellular events intimately associated with Alzheimer’s disease including calcium channel function, cholesterol metabolism, neuroinflammation, endocytosis, cell cycle events, and apoptosis have been tentatively or experimentally verified as calmodulin binding proteins. The use of calmodulin as a potential biomarker and as a therapeutic target is discussed. |
format | Online Article Text |
id | pubmed-4878311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48783112016-06-09 Calmodulin Binding Proteins and Alzheimer’s Disease O’Day, Danton H. Eshak, Kristeen Myre, Michael A. J Alzheimers Dis Review The small, calcium-sensor protein, calmodulin, is ubiquitously expressed and central to cell function in all cell types. Here the literature linking calmodulin to Alzheimer’s disease is reviewed. Several experimentally-verified calmodulin-binding proteins are involved in the formation of amyloid-β plaques including amyloid-β protein precursor, β-secretase, presenilin-1, and ADAM10. Many others possess potential calmodulin-binding domains that remain to be verified. Three calmodulin binding proteins are associated with the formation of neurofibrillary tangles: two kinases (CaMKII, CDK5) and one protein phosphatase (PP2B or calcineurin). Many of the genes recently identified by genome wide association studies and other studies encode proteins that contain putative calmodulin-binding domains but only a couple (e.g., APOE, BIN1) have been experimentally confirmed as calmodulin binding proteins. At least two receptors involved in calcium metabolism and linked to Alzheimer’s disease (mAchR; NMDAR) have also been identified as calmodulin-binding proteins. In addition to this, many proteins that are involved in other cellular events intimately associated with Alzheimer’s disease including calcium channel function, cholesterol metabolism, neuroinflammation, endocytosis, cell cycle events, and apoptosis have been tentatively or experimentally verified as calmodulin binding proteins. The use of calmodulin as a potential biomarker and as a therapeutic target is discussed. IOS Press 2015-06-25 /pmc/articles/PMC4878311/ /pubmed/25812852 http://dx.doi.org/10.3233/JAD-142772 Text en IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License. |
spellingShingle | Review O’Day, Danton H. Eshak, Kristeen Myre, Michael A. Calmodulin Binding Proteins and Alzheimer’s Disease |
title | Calmodulin Binding Proteins and Alzheimer’s Disease |
title_full | Calmodulin Binding Proteins and Alzheimer’s Disease |
title_fullStr | Calmodulin Binding Proteins and Alzheimer’s Disease |
title_full_unstemmed | Calmodulin Binding Proteins and Alzheimer’s Disease |
title_short | Calmodulin Binding Proteins and Alzheimer’s Disease |
title_sort | calmodulin binding proteins and alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878311/ https://www.ncbi.nlm.nih.gov/pubmed/25812852 http://dx.doi.org/10.3233/JAD-142772 |
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