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Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions
Astrocytes play critical roles in neuronal activity and inhibition of regeneration. Here we show that the cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of TGF-β sig...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878404/ https://www.ncbi.nlm.nih.gov/pubmed/26120963 http://dx.doi.org/10.1038/nn.4054 |
| _version_ | 1782433562320961536 |
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| author | Schachtrup, Christian Ryu, Jae Kyu Mammadzada, Könül Khan, Abdullah S. Carlton, Peter M. Perez, Alex Christian, Frank Le Moan, Natacha Vagena, Eirini Baeza-Raja, Bernat Rafalski, Victoria Chan, Justin P. Nitschke, Roland Houslay, Miles D. Ellisman, Mark H. Wyss-Coray, Tony Palop, Jorge J. Akassoglou, Katerina |
| author_facet | Schachtrup, Christian Ryu, Jae Kyu Mammadzada, Könül Khan, Abdullah S. Carlton, Peter M. Perez, Alex Christian, Frank Le Moan, Natacha Vagena, Eirini Baeza-Raja, Bernat Rafalski, Victoria Chan, Justin P. Nitschke, Roland Houslay, Miles D. Ellisman, Mark H. Wyss-Coray, Tony Palop, Jorge J. Akassoglou, Katerina |
| author_sort | Schachtrup, Christian |
| collection | PubMed |
| description | Astrocytes play critical roles in neuronal activity and inhibition of regeneration. Here we show that the cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of TGF-β signaling. The cleaved p75(NTR) interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-neuronal communication in response to profibrotic factors. |
| format | Online Article Text |
| id | pubmed-4878404 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-48784042016-05-24 Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions Schachtrup, Christian Ryu, Jae Kyu Mammadzada, Könül Khan, Abdullah S. Carlton, Peter M. Perez, Alex Christian, Frank Le Moan, Natacha Vagena, Eirini Baeza-Raja, Bernat Rafalski, Victoria Chan, Justin P. Nitschke, Roland Houslay, Miles D. Ellisman, Mark H. Wyss-Coray, Tony Palop, Jorge J. Akassoglou, Katerina Nat Neurosci Article Astrocytes play critical roles in neuronal activity and inhibition of regeneration. Here we show that the cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of TGF-β signaling. The cleaved p75(NTR) interacts with nucleoporins to promote Smad2 nucleocytoplasmic shuttling. Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-neuronal communication in response to profibrotic factors. 2015-06-29 2015-08 /pmc/articles/PMC4878404/ /pubmed/26120963 http://dx.doi.org/10.1038/nn.4054 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Schachtrup, Christian Ryu, Jae Kyu Mammadzada, Könül Khan, Abdullah S. Carlton, Peter M. Perez, Alex Christian, Frank Le Moan, Natacha Vagena, Eirini Baeza-Raja, Bernat Rafalski, Victoria Chan, Justin P. Nitschke, Roland Houslay, Miles D. Ellisman, Mark H. Wyss-Coray, Tony Palop, Jorge J. Akassoglou, Katerina Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions |
| title | Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions |
| title_full | Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions |
| title_fullStr | Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions |
| title_full_unstemmed | Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions |
| title_short | Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions |
| title_sort | nuclear pore complex remodeling by p75(ntr) cleavage controls tgf-β signaling and astrocyte functions |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878404/ https://www.ncbi.nlm.nih.gov/pubmed/26120963 http://dx.doi.org/10.1038/nn.4054 |
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