Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance

Insulin controls glucose uptake into adipose and muscle cells by regulating the amount of GLUT4 in the plasma membrane. The effect of insulin is to promote the translocation of intracellular GLUT4 to the plasma membrane. The small Rab GTPase, Rab10, is required for insulin-stimulated GLUT4 transloca...

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Detalles Bibliográficos
Autores principales: Vazirani, Reema P., Verma, Akanksha, Sadacca, L. Amanda, Buckman, Melanie S., Picatoste, Belen, Beg, Muheeb, Torsitano, Christopher, Bruno, Joanne H., Patel, Rajesh T., Simonyte, Kotryna, Camporez, Joao P., Moreira, Gabriela, Falcone, Domenick J., Accili, Domenico, Elemento, Olivier, Shulman, Gerald I., Kahn, Barbara B., McGraw, Timothy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878419/
https://www.ncbi.nlm.nih.gov/pubmed/27207531
http://dx.doi.org/10.2337/db15-1128

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