Role of GCN2-Independent Signaling Through a Noncanonical PERK/NRF2 Pathway in the Physiological Responses to Dietary Methionine Restriction

Restricting availability of essential amino acids (EAAs) limits aminoacylation of tRNAs by their cognate EAAs and activates the nutrient-sensing kinase, general control nonderepressible 2 (GCN2). Activated GCN2 phosphorylates eukaryotic initiation factor 2 (eIF2), altering gene-specific translation...

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Detalles Bibliográficos
Autores principales: Wanders, Desiree, Stone, Kirsten P., Forney, Laura A., Cortez, Cory C., Dille, Kelly N., Simon, Jacob, Xu, Mark, Hotard, Elisabeth C., Nikonorova, Inna A., Pettit, Ashley P., Anthony, Tracy G., Gettys, Thomas W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2016
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878423/
https://www.ncbi.nlm.nih.gov/pubmed/26936965
http://dx.doi.org/10.2337/db15-1324

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