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The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice

Congenital hyperinsulinism of infancy (CHI) can be caused by inactivating mutations in the gene encoding short-chain 3-hydroxyacyl-CoA dehydrogenase (SCHAD), a ubiquitously expressed enzyme involved in fatty acid oxidation. The hypersecretion of insulin may be explained by a loss of interaction betw...

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Detalles Bibliográficos
Autores principales:	Molven, Anders, Hollister-Lock, Jennifer, Hu, Jiang, Martinez, Rachael, Njølstad, Pål R., Liew, Chong Wee, Weir, Gordon, Kulkarni, Rohit N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878426/ https://www.ncbi.nlm.nih.gov/pubmed/26953163 http://dx.doi.org/10.2337/db15-1475

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