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Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy

The mechanisms for the development of diabetic cardiomyopathy remain largely unknown. Methylglyoxal (MG) can accumulate and promote inflammation and vascular damage in diabetes. We examined if overexpression of the MG-metabolizing enzyme glyoxalase 1 (GLO1) in macrophages and the vasculature could r...

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Detalles Bibliográficos
Autores principales:	Vulesevic, Branka, McNeill, Brian, Giacco, Ferdinando, Maeda, Kay, Blackburn, Nick J.R., Brownlee, Michael, Milne, Ross W., Suuronen, Erik J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2016
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878427/ https://www.ncbi.nlm.nih.gov/pubmed/26956489 http://dx.doi.org/10.2337/db15-0568

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