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Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis

Psoriasis is a common chronic inflammatory and T cell-meditated skin disease. Runt-related transcription factor 3 (RUNX3), one of the runt-domain family of transcription factors, has been reported to be a susceptibility gene for psoriasis. The present study was designed to delineate the role and und...

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Autores principales: FU, DANDAN, SONG, XIANGFENG, HU, HUA, SUN, MIN, LI, ZHANGUO, TIAN, ZHONGWEI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878538/
https://www.ncbi.nlm.nih.gov/pubmed/27082311
http://dx.doi.org/10.3892/mmr.2016.5108
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author FU, DANDAN
SONG, XIANGFENG
HU, HUA
SUN, MIN
LI, ZHANGUO
TIAN, ZHONGWEI
author_facet FU, DANDAN
SONG, XIANGFENG
HU, HUA
SUN, MIN
LI, ZHANGUO
TIAN, ZHONGWEI
author_sort FU, DANDAN
collection PubMed
description Psoriasis is a common chronic inflammatory and T cell-meditated skin disease. Runt-related transcription factor 3 (RUNX3), one of the runt-domain family of transcription factors, has been reported to be a susceptibility gene for psoriasis. The present study was designed to delineate the role and underlying mechanism of RUNX3 involved in the differentiation of T helper (Th) 17 and Th22 cells in psoriasis. The results of the present study demonstrated that the expression of RUNX3 increased significantly in CD4-positive (CD4(+)) T cells from patients with psoriasis, compared with healthy controls. In addition, increased levels of interleukin (IL)-6, IL-20 and IL-22, and increased frequencies of Th17 and Th22 cells were found in the patients with psoriasis patients, compared with the healthy controls. It was also found that the overexpression of RUNX3 increased the levels of Th17- and Th22-associated cytokines in the CD4(+) T cells from the healthy controls. However, the inhibition of RUNX3 reduced the levels of the associated cytokines and decreased the frequency of Th17 and Th22 cells in the CD4(+) T cells from the patients with psoriasis. Taken together, the present study suggested that RUNX3 regulated the differentiation of Th17 and Th22 cells in psoriasis, providing a promising therapeutic strategy for the treatment of psoriasis.
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spelling pubmed-48785382016-05-25 Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis FU, DANDAN SONG, XIANGFENG HU, HUA SUN, MIN LI, ZHANGUO TIAN, ZHONGWEI Mol Med Rep Articles Psoriasis is a common chronic inflammatory and T cell-meditated skin disease. Runt-related transcription factor 3 (RUNX3), one of the runt-domain family of transcription factors, has been reported to be a susceptibility gene for psoriasis. The present study was designed to delineate the role and underlying mechanism of RUNX3 involved in the differentiation of T helper (Th) 17 and Th22 cells in psoriasis. The results of the present study demonstrated that the expression of RUNX3 increased significantly in CD4-positive (CD4(+)) T cells from patients with psoriasis, compared with healthy controls. In addition, increased levels of interleukin (IL)-6, IL-20 and IL-22, and increased frequencies of Th17 and Th22 cells were found in the patients with psoriasis patients, compared with the healthy controls. It was also found that the overexpression of RUNX3 increased the levels of Th17- and Th22-associated cytokines in the CD4(+) T cells from the healthy controls. However, the inhibition of RUNX3 reduced the levels of the associated cytokines and decreased the frequency of Th17 and Th22 cells in the CD4(+) T cells from the patients with psoriasis. Taken together, the present study suggested that RUNX3 regulated the differentiation of Th17 and Th22 cells in psoriasis, providing a promising therapeutic strategy for the treatment of psoriasis. D.A. Spandidos 2016-06 2016-04-12 /pmc/articles/PMC4878538/ /pubmed/27082311 http://dx.doi.org/10.3892/mmr.2016.5108 Text en Copyright: © Fu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
FU, DANDAN
SONG, XIANGFENG
HU, HUA
SUN, MIN
LI, ZHANGUO
TIAN, ZHONGWEI
Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis
title Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis
title_full Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis
title_fullStr Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis
title_full_unstemmed Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis
title_short Downregulation of RUNX3 moderates the frequency of Th17 and Th22 cells in patients with psoriasis
title_sort downregulation of runx3 moderates the frequency of th17 and th22 cells in patients with psoriasis
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878538/
https://www.ncbi.nlm.nih.gov/pubmed/27082311
http://dx.doi.org/10.3892/mmr.2016.5108
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