Cargando…

Post-translational modifications of α-synuclein contribute to neurodegeneration in the colon of elderly individuals

Synucleinopathies and abnormalities in the nerves of the enteric nervous system are hypothesized to be involved in age-associated motility disorders. The aim of the present study was to investigate the expression of various antigens, including α-synuclein (Syn) and its post-translational modified fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	XUAN, QI, ZHANG, YU-XIAN, LIU, DIAN-GANG, CHAN, PIU, XU, SHENG-LI, CUI, YE-QING
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878562/ https://www.ncbi.nlm.nih.gov/pubmed/27109489 http://dx.doi.org/10.3892/mmr.2016.5166

Ejemplares similares

Neurodegeneration and the ordered assembly of α-synuclein
por: Spillantini, Maria Grazia, et al.
Publicado: (2017)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

Cerebrospinal fluid α-synuclein predicts neurodegeneration and clinical progression in non-demented elders
por: Li, Jie-Qiong, et al.
Publicado: (2020)

The Roles of Post-translational Modifications on α-Synuclein in the Pathogenesis of Parkinson’s Diseases
por: Zhang, Jiaming, et al.
Publicado: (2019)

Targeted proteolytic products of τ and α-synuclein in neurodegeneration
por: Xia, Yuxing, et al.
Publicado: (2021)

Modulation of the Interactions Between α-Synuclein and Lipid Membranes by Post-translational Modifications
por: Bell, Rosie, et al.
Publicado: (2021)

Proteomics of protein post-translational modifications implicated in neurodegeneration
por: Ren, Ru-Jing, et al.
Publicado: (2014)

Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2020)

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice
por: Gu, Xing-Long, et al.
Publicado: (2010)

Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization
por: Calogero, Alessandra Maria, et al.
Publicado: (2023)

Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration
por: Hastings, Lyndsay, et al.
Publicado: (2022)

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila
por: Bridi, Jessika C, et al.
Publicado: (2021)

Alpha Synuclein: Neurodegeneration and Inflammation
por: Forloni, Gianluigi
Publicado: (2023)

Age- and brain region-dependent α-synuclein oligomerization is attributed to alterations in intrinsic enzymes regulating α-synuclein phosphorylation in aging monkey brains
por: Chen, Min, et al.
Publicado: (2015)

α-Synuclein Modification in an ALS Animal Model
por: Yang, Eun Jin, et al.
Publicado: (2013)

α‐Synuclein aggregation causes muscle atrophy through neuromuscular junction degeneration
por: Yang, Qiumei, et al.
Publicado: (2022)

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds
por: Macdonald, Jennifer A., et al.
Publicado: (2021)

Selective neurodegeneration generated by intravenous α‐synuclein pre‐formed fibril administration is not associated with endogenous α‐synuclein levels in the rat brain
por: Kuan, Wei‐Li, et al.
Publicado: (2022)

Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein
por: Sawada, Hideyuki, et al.
Publicado: (2013)

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration
por: Davis, Marie Y., et al.
Publicado: (2016)

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression
por: Bourdenx, Mathieu, et al.
Publicado: (2015)

α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration
por: Fecchio, Chiara, et al.
Publicado: (2018)

Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease
por: Mori, Akio, et al.
Publicado: (2020)

α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox
por: Simon, Christopher, et al.
Publicado: (2021)

Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction
por: Dues, Dylan J., et al.
Publicado: (2023)

Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction
por: Dues, Dylan J., et al.
Publicado: (2023)

Alpha-synuclein and tau: teammates in neurodegeneration?
por: Moussaud, Simon, et al.
Publicado: (2014)

Interaction between Neuromelanin and Alpha-Synuclein in Parkinson’s Disease
por: Xu, Shengli, et al.
Publicado: (2015)

Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2015)

A Powerful Yeast Model to Investigate the Synergistic Interaction of α-Synuclein and Tau in Neurodegeneration
por: Ciaccioli, Gianmario, et al.
Publicado: (2013)

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration
por: Harms, Ashley S., et al.
Publicado: (2017)

Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease
por: Hu, Shanshan, et al.
Publicado: (2020)

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration
por: Choi, Insup, et al.
Publicado: (2020)

Interactions between Calcium and Alpha-Synuclein in Neurodegeneration
por: Rcom-H’cheo-Gauthier, Alex, et al.
Publicado: (2014)

Neurodegeneration and contralateral α-synuclein induction after intracerebral α-synuclein injections in the anterior olfactory nucleus of a Parkinson’s disease A53T mouse model
por: Flores-Cuadrado, Alicia, et al.
Publicado: (2019)

Poly (ADP‐ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α‐synuclein degradation via transcription factor EB‐dependent autophagy in mutant α‐synucleinA53T model of Parkinson's disease
por: Mao, Kanmin, et al.
Publicado: (2020)

Electroacupuncture remediates glial dysfunction and ameliorates neurodegeneration in the astrocytic α-synuclein mutant mouse model
por: Deng, Jiahui, et al.
Publicado: (2015)

Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?
por: Post, Michael R., et al.
Publicado: (2018)

Decelerated neurodegeneration after intravitreal injection of α-synuclein antibodies in a glaucoma animal model
por: Teister, J., et al.
Publicado: (2017)

Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
por: Arotcarena, Marie‐Laure, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rmn713sl7ls4005dva9nqsicuq