Orotate phosphoribosyltransferase is overexpressed in malignant pleural mesothelioma: Dramatically responds one case in high OPRT expression

Objective: Malignant pleural mesothelioma (MPM) is a rare and aggressive, treatment-resistant cancer. Pemetrexed, an inhibitor of thymidylate synthase (TS), is used worldwide for MPM as a first-line chemotherapy regimen. However, there is little consensus for a second-line chemotherapy. S-1, a highl...

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Detalles Bibliográficos
Autores principales: Hamamoto, Yoichiro, Takeoka, Shinjiro, Mouri, Atsuto, Fukusumi, Munehisa, Wakuda, Kazushige, Ibe, Tatsuya, Honma, Chie, Arimoto, Yoshihito, Yamada, Kazuaki, Wagatsuma, Miyuki, Tashiro, Akito, Kamoshida, Shingo, Kamimura, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878580/
https://www.ncbi.nlm.nih.gov/pubmed/27274438
http://dx.doi.org/10.1080/21675511.2016.1165909

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