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Relevance of prehypertension as a diagnostic category in asymptomatic adults

OBJECTIVE: To assess the association of prehypertension with metabolic, inflammatory and cardiovascular risk profile in asymptomatic individuals. METHODS: Between 2006 and 2009, 11,011 asymptomatic adults (mean age: 43 years; 22% females), underwent a check-up protocol. They were divided into 3 grou...

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Autores principales: Nary, Fernando Costa, Santos, Raul D., Laurinavicius, Antonio Gabriele, Conceição, Raquel Dilguerian de Oliveira, de Carvalho, José Antonio Maluf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878588/
https://www.ncbi.nlm.nih.gov/pubmed/24136756
http://dx.doi.org/10.1590/S1679-45082013000300008
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author Nary, Fernando Costa
Santos, Raul D.
Laurinavicius, Antonio Gabriele
Conceição, Raquel Dilguerian de Oliveira
de Carvalho, José Antonio Maluf
author_facet Nary, Fernando Costa
Santos, Raul D.
Laurinavicius, Antonio Gabriele
Conceição, Raquel Dilguerian de Oliveira
de Carvalho, José Antonio Maluf
author_sort Nary, Fernando Costa
collection PubMed
description OBJECTIVE: To assess the association of prehypertension with metabolic, inflammatory and cardiovascular risk profile in asymptomatic individuals. METHODS: Between 2006 and 2009, 11,011 asymptomatic adults (mean age: 43 years; 22% females), underwent a check-up protocol. They were divided into 3 groups: normotensive group (arterial pressure=120/80mmHg), prehypertensive group (arterial pressure >120/80mmHg and <140/90mmHg) and hypertensive group (arterial pressure≥140/90mmHg or prior diagnosis of hypertension). Each group metabolic and cardiovascular group profile was assessed. RESULTS: The prevalence of normotension, prehypertension and hypertension was 27.9%, 53.9% and 18.2%, respectively. Prehypertensive individuals were older (mean age: 42.7 versus 40 years; p<0.001) than normotensive patients, and had higher body mass index (mean: 26.7kg/m(2) versus 24kg/m(2); p<0.001), higher plasma triglycerides levels (mean: 139mg/dL versus 108mg/dL; p<0.001), higher LDL-choleterol levels (mean: 128mg/dL versus 117mg/dL; p<0.001), and lower HDL-cholesterol (mean: 46.7mg/dL versus 52.7mg/dL; p<0.001). Prehypertensive individuals were more likely to have impaired fasting glucose (OR: 1.69; 95%CI: 1.39-2.04), overweight and obesity - body mass index >25kg/m(2) (OR: 2.48; 95%CI: 2.24-2.74), hepatic steatosis: (OR: 2.23; 95%CI: 1.97-2.53), metabolic syndrome (OR: 3.05; 95%CI: 2.67-3.49), and high-sensitivity C-reactive protein levels>2mg/L (OR: 1.52; 95%CI: 1.35-1.71). CONCLUSION: Prehypertension is associated with an increased prevalence of metabolic syndrome, hepatic steatosis and subclinical inflammation.
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spelling pubmed-48785882016-08-10 Relevance of prehypertension as a diagnostic category in asymptomatic adults Nary, Fernando Costa Santos, Raul D. Laurinavicius, Antonio Gabriele Conceição, Raquel Dilguerian de Oliveira de Carvalho, José Antonio Maluf Einstein (Sao Paulo) Original Article OBJECTIVE: To assess the association of prehypertension with metabolic, inflammatory and cardiovascular risk profile in asymptomatic individuals. METHODS: Between 2006 and 2009, 11,011 asymptomatic adults (mean age: 43 years; 22% females), underwent a check-up protocol. They were divided into 3 groups: normotensive group (arterial pressure=120/80mmHg), prehypertensive group (arterial pressure >120/80mmHg and <140/90mmHg) and hypertensive group (arterial pressure≥140/90mmHg or prior diagnosis of hypertension). Each group metabolic and cardiovascular group profile was assessed. RESULTS: The prevalence of normotension, prehypertension and hypertension was 27.9%, 53.9% and 18.2%, respectively. Prehypertensive individuals were older (mean age: 42.7 versus 40 years; p<0.001) than normotensive patients, and had higher body mass index (mean: 26.7kg/m(2) versus 24kg/m(2); p<0.001), higher plasma triglycerides levels (mean: 139mg/dL versus 108mg/dL; p<0.001), higher LDL-choleterol levels (mean: 128mg/dL versus 117mg/dL; p<0.001), and lower HDL-cholesterol (mean: 46.7mg/dL versus 52.7mg/dL; p<0.001). Prehypertensive individuals were more likely to have impaired fasting glucose (OR: 1.69; 95%CI: 1.39-2.04), overweight and obesity - body mass index >25kg/m(2) (OR: 2.48; 95%CI: 2.24-2.74), hepatic steatosis: (OR: 2.23; 95%CI: 1.97-2.53), metabolic syndrome (OR: 3.05; 95%CI: 2.67-3.49), and high-sensitivity C-reactive protein levels>2mg/L (OR: 1.52; 95%CI: 1.35-1.71). CONCLUSION: Prehypertension is associated with an increased prevalence of metabolic syndrome, hepatic steatosis and subclinical inflammation. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2013 /pmc/articles/PMC4878588/ /pubmed/24136756 http://dx.doi.org/10.1590/S1679-45082013000300008 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Nary, Fernando Costa
Santos, Raul D.
Laurinavicius, Antonio Gabriele
Conceição, Raquel Dilguerian de Oliveira
de Carvalho, José Antonio Maluf
Relevance of prehypertension as a diagnostic category in asymptomatic adults
title Relevance of prehypertension as a diagnostic category in asymptomatic adults
title_full Relevance of prehypertension as a diagnostic category in asymptomatic adults
title_fullStr Relevance of prehypertension as a diagnostic category in asymptomatic adults
title_full_unstemmed Relevance of prehypertension as a diagnostic category in asymptomatic adults
title_short Relevance of prehypertension as a diagnostic category in asymptomatic adults
title_sort relevance of prehypertension as a diagnostic category in asymptomatic adults
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878588/
https://www.ncbi.nlm.nih.gov/pubmed/24136756
http://dx.doi.org/10.1590/S1679-45082013000300008
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