Disruption of ribosome assembly in yeast blocks cotranscriptional pre-rRNA processing and affects the global hierarchy of ribosome biogenesis

In higher eukaryotes, pre-rRNA processing occurs almost exclusively post-transcriptionally. This is not the case in rapidly dividing yeast, as the majority of nascent pre-rRNAs are processed cotranscriptionally, with cleavage at the A(2) site first releasing a pre-40S ribosomal subunit followed by r...

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Detalles Bibliográficos
Autores principales: Talkish, Jason, Biedka, Stephanie, Jakovljevic, Jelena, Zhang, Jingyu, Tang, Lan, Strahler, John R., Andrews, Philip C., Maddock, Janine R., Woolford, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878612/
https://www.ncbi.nlm.nih.gov/pubmed/27036125
http://dx.doi.org/10.1261/rna.055780.115

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