Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle

The COP9-Signalosome (CSN) regulates cullin–RING ubiquitin ligase (CRL) activity and assembly by cleaving Nedd8 from cullins. Free CSN is autoinhibited, and it remains unclear how it becomes activated. We combine structural and kinetic analyses to identify mechanisms that contribute to CSN activatio...

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Detalles Bibliográficos
Autores principales: Mosadeghi, Ruzbeh, Reichermeier, Kurt M, Winkler, Martin, Schreiber, Anne, Reitsma, Justin M, Zhang, Yaru, Stengel, Florian, Cao, Junyue, Kim, Minsoo, Sweredoski, Michael J, Hess, Sonja, Leitner, Alexander, Aebersold, Ruedi, Peter, Matthias, Deshaies, Raymond J, Enchev, Radoslav I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878873/
https://www.ncbi.nlm.nih.gov/pubmed/27031283
http://dx.doi.org/10.7554/eLife.12102

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