Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth factor-I

The role of endocrine IGF-I for atherosclerosis is unclear. We determined the importance of circulating, liver-derived IGF-I for fatty streak formation in mice. Mice with adult, liver-specific IGF-I inactivation (LI-IGF-I(−/−) mice, serum IGF-I reduced by approximately 80 %) and control mice receive...

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Detalles Bibliográficos
Autores principales: Svensson, Johan, Sjögren, Klara, Levin, Malin, Borén, Jan, Tivesten, Åsa, Ohlsson, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879167/
https://www.ncbi.nlm.nih.gov/pubmed/26627099
http://dx.doi.org/10.1007/s12020-015-0809-1

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