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Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients

OBJECTIVES: This study aimed to estimate the prevalence of diabetes mellitus (DM) in hospitalized patients with community-acquired pneumonia (CAP) and its impact on hospital length of stay and in-hospital mortality. RESEARCH DESIGN AND METHODS: We carried out a retrospective, nationwide register ana...

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Autores principales: Martins, M, Boavida, J M, Raposo, J F, Froes, F, Nunes, B, Ribeiro, R T, Macedo, M P, Penha-Gonçalves, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879333/
https://www.ncbi.nlm.nih.gov/pubmed/27252873
http://dx.doi.org/10.1136/bmjdrc-2015-000181
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author Martins, M
Boavida, J M
Raposo, J F
Froes, F
Nunes, B
Ribeiro, R T
Macedo, M P
Penha-Gonçalves, C
author_facet Martins, M
Boavida, J M
Raposo, J F
Froes, F
Nunes, B
Ribeiro, R T
Macedo, M P
Penha-Gonçalves, C
author_sort Martins, M
collection PubMed
description OBJECTIVES: This study aimed to estimate the prevalence of diabetes mellitus (DM) in hospitalized patients with community-acquired pneumonia (CAP) and its impact on hospital length of stay and in-hospital mortality. RESEARCH DESIGN AND METHODS: We carried out a retrospective, nationwide register analysis of CAP in adult patients admitted to Portuguese hospitals between 2009 and 2012. Anonymous data from 157 291 adult patients with CAP were extracted from the National Hospital Discharge Database and we performed a DM-conditioned analysis stratified by age, sex and year of hospitalization. RESULTS: The 74 175 CAP episodes that matched the inclusion criteria showed a high burden of DM that tended to increase over time, from 23.7% in 2009 to 28.1% in 2012. Interestingly, patients with CAP had high DM prevalence in the context of the national DM prevalence. Episodes of CAP in patients with DM had on average 0.8 days longer hospital stay as compared to patients without DM (p<0.0001), totaling a surplus of 15 370 days of stay attributable to DM in 19 212 admissions. In-hospital mortality was also significantly higher in patients with CAP who have DM (15.2%) versus those who have DM (13.5%) (p=0.002). CONCLUSIONS: Our analysis revealed that DM prevalence was significantly increased within CAP hospital admissions, reinforcing other studies’ findings that suggest that DM is a risk factor for CAP. Since patients with CAP who have DM have longer hospitalization time and higher mortality rates, these results hold informative value for patient guidance and healthcare strategies.
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spelling pubmed-48793332016-06-01 Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients Martins, M Boavida, J M Raposo, J F Froes, F Nunes, B Ribeiro, R T Macedo, M P Penha-Gonçalves, C BMJ Open Diabetes Res Care Epidemiology/Health Services Research OBJECTIVES: This study aimed to estimate the prevalence of diabetes mellitus (DM) in hospitalized patients with community-acquired pneumonia (CAP) and its impact on hospital length of stay and in-hospital mortality. RESEARCH DESIGN AND METHODS: We carried out a retrospective, nationwide register analysis of CAP in adult patients admitted to Portuguese hospitals between 2009 and 2012. Anonymous data from 157 291 adult patients with CAP were extracted from the National Hospital Discharge Database and we performed a DM-conditioned analysis stratified by age, sex and year of hospitalization. RESULTS: The 74 175 CAP episodes that matched the inclusion criteria showed a high burden of DM that tended to increase over time, from 23.7% in 2009 to 28.1% in 2012. Interestingly, patients with CAP had high DM prevalence in the context of the national DM prevalence. Episodes of CAP in patients with DM had on average 0.8 days longer hospital stay as compared to patients without DM (p<0.0001), totaling a surplus of 15 370 days of stay attributable to DM in 19 212 admissions. In-hospital mortality was also significantly higher in patients with CAP who have DM (15.2%) versus those who have DM (13.5%) (p=0.002). CONCLUSIONS: Our analysis revealed that DM prevalence was significantly increased within CAP hospital admissions, reinforcing other studies’ findings that suggest that DM is a risk factor for CAP. Since patients with CAP who have DM have longer hospitalization time and higher mortality rates, these results hold informative value for patient guidance and healthcare strategies. BMJ Publishing Group 2016-05-20 /pmc/articles/PMC4879333/ /pubmed/27252873 http://dx.doi.org/10.1136/bmjdrc-2015-000181 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Epidemiology/Health Services Research
Martins, M
Boavida, J M
Raposo, J F
Froes, F
Nunes, B
Ribeiro, R T
Macedo, M P
Penha-Gonçalves, C
Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients
title Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients
title_full Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients
title_fullStr Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients
title_full_unstemmed Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients
title_short Diabetes hinders community-acquired pneumonia outcomes in hospitalized patients
title_sort diabetes hinders community-acquired pneumonia outcomes in hospitalized patients
topic Epidemiology/Health Services Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879333/
https://www.ncbi.nlm.nih.gov/pubmed/27252873
http://dx.doi.org/10.1136/bmjdrc-2015-000181
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