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A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium

INTRODUCTION: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating an...

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Autores principales: Adams, Hieab H.H., Hilal, Saima, Schwingenschuh, Petra, Wittfeld, Katharina, van der Lee, Sven J., DeCarli, Charles, Vernooij, Meike W., Katschnig-Winter, Petra, Habes, Mohamad, Chen, Christopher, Seshadri, Sudha, van Duijn, Cornelia M., Ikram, M. Kamran, Grabe, Hans J., Schmidt, Reinhold, Ikram, M. Arfan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879491/
https://www.ncbi.nlm.nih.gov/pubmed/27239529
http://dx.doi.org/10.1016/j.dadm.2015.10.004
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author Adams, Hieab H.H.
Hilal, Saima
Schwingenschuh, Petra
Wittfeld, Katharina
van der Lee, Sven J.
DeCarli, Charles
Vernooij, Meike W.
Katschnig-Winter, Petra
Habes, Mohamad
Chen, Christopher
Seshadri, Sudha
van Duijn, Cornelia M.
Ikram, M. Kamran
Grabe, Hans J.
Schmidt, Reinhold
Ikram, M. Arfan
author_facet Adams, Hieab H.H.
Hilal, Saima
Schwingenschuh, Petra
Wittfeld, Katharina
van der Lee, Sven J.
DeCarli, Charles
Vernooij, Meike W.
Katschnig-Winter, Petra
Habes, Mohamad
Chen, Christopher
Seshadri, Sudha
van Duijn, Cornelia M.
Ikram, M. Kamran
Grabe, Hans J.
Schmidt, Reinhold
Ikram, M. Arfan
author_sort Adams, Hieab H.H.
collection PubMed
description INTRODUCTION: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field. METHODS: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium. RESULTS: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region. DISCUSSION: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia.
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spelling pubmed-48794912016-05-27 A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium Adams, Hieab H.H. Hilal, Saima Schwingenschuh, Petra Wittfeld, Katharina van der Lee, Sven J. DeCarli, Charles Vernooij, Meike W. Katschnig-Winter, Petra Habes, Mohamad Chen, Christopher Seshadri, Sudha van Duijn, Cornelia M. Ikram, M. Kamran Grabe, Hans J. Schmidt, Reinhold Ikram, M. Arfan Alzheimers Dement (Amst) Neuroimaging INTRODUCTION: Virchow-Robin spaces (VRS), or perivascular spaces, are compartments of interstitial fluid enclosing cerebral blood vessels and are potential imaging markers of various underlying brain pathologies. Despite a growing interest in the study of enlarged VRS, the heterogeneity in rating and quantification methods combined with small sample sizes have so far hampered advancement in the field. METHODS: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement (UNIVRSE) consortium was established with primary aims to harmonize rating and analysis (www.uconsortium.org). The UNIVRSE consortium brings together 13 (sub)cohorts from five countries, totaling 16,000 subjects and over 25,000 scans. Eight different magnetic resonance imaging protocols were used in the consortium. RESULTS: VRS rating was harmonized using a validated protocol that was developed by the two founding members, with high reliability independent of scanner type, rater experience, or concomitant brain pathology. Initial analyses revealed risk factors for enlarged VRS including increased age, sex, high blood pressure, brain infarcts, and white matter lesions, but this varied by brain region. DISCUSSION: Early collaborative efforts between cohort studies with respect to data harmonization and joint analyses can advance the field of population (neuro)imaging. The UNIVRSE consortium will focus efforts on other potential correlates of enlarged VRS, including genetics, cognition, stroke, and dementia. Elsevier 2015-10-31 /pmc/articles/PMC4879491/ /pubmed/27239529 http://dx.doi.org/10.1016/j.dadm.2015.10.004 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Neuroimaging
Adams, Hieab H.H.
Hilal, Saima
Schwingenschuh, Petra
Wittfeld, Katharina
van der Lee, Sven J.
DeCarli, Charles
Vernooij, Meike W.
Katschnig-Winter, Petra
Habes, Mohamad
Chen, Christopher
Seshadri, Sudha
van Duijn, Cornelia M.
Ikram, M. Kamran
Grabe, Hans J.
Schmidt, Reinhold
Ikram, M. Arfan
A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium
title A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium
title_full A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium
title_fullStr A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium
title_full_unstemmed A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium
title_short A priori collaboration in population imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement consortium
title_sort priori collaboration in population imaging: the uniform neuro-imaging of virchow-robin spaces enlargement consortium
topic Neuroimaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879491/
https://www.ncbi.nlm.nih.gov/pubmed/27239529
http://dx.doi.org/10.1016/j.dadm.2015.10.004
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