A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients

A new species of torque teno mini virus, named TTMV-222, was detected in gingival tissue from periodontitis patients using a viral metagenomics method. The 2803-nucleotide genome of TTMV-222 is closely related to TTMV1-CBD279, with 62.6% overall nucleotide similarity. Genetic analyses of the new vir...

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Autores principales: Zhang, Yu, Li, Fei, Shan, Tong-Ling, Deng, Xutao, Delwart, Eric, Feng, Xi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879676/
https://www.ncbi.nlm.nih.gov/pubmed/27221159
http://dx.doi.org/10.1038/srep26739
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author Zhang, Yu
Li, Fei
Shan, Tong-Ling
Deng, Xutao
Delwart, Eric
Feng, Xi-Ping
author_facet Zhang, Yu
Li, Fei
Shan, Tong-Ling
Deng, Xutao
Delwart, Eric
Feng, Xi-Ping
author_sort Zhang, Yu
collection PubMed
description A new species of torque teno mini virus, named TTMV-222, was detected in gingival tissue from periodontitis patients using a viral metagenomics method. The 2803-nucleotide genome of TTMV-222 is closely related to TTMV1-CBD279, with 62.6% overall nucleotide similarity. Genetic analyses of the new virus genome revealed a classic genomic organization but a weak identity with known sequences. The prevalence of TTMV-222 in the periodontitis group (n = 150) was significantly higher than that in the healthy group (n = 150) (p = 0.032), suggesting that the new virus may be associated with inflammation in chronic periodontitis patients. However, this finding requires further investigation.
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spelling pubmed-48796762016-06-07 A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients Zhang, Yu Li, Fei Shan, Tong-Ling Deng, Xutao Delwart, Eric Feng, Xi-Ping Sci Rep Article A new species of torque teno mini virus, named TTMV-222, was detected in gingival tissue from periodontitis patients using a viral metagenomics method. The 2803-nucleotide genome of TTMV-222 is closely related to TTMV1-CBD279, with 62.6% overall nucleotide similarity. Genetic analyses of the new virus genome revealed a classic genomic organization but a weak identity with known sequences. The prevalence of TTMV-222 in the periodontitis group (n = 150) was significantly higher than that in the healthy group (n = 150) (p = 0.032), suggesting that the new virus may be associated with inflammation in chronic periodontitis patients. However, this finding requires further investigation. Nature Publishing Group 2016-05-25 /pmc/articles/PMC4879676/ /pubmed/27221159 http://dx.doi.org/10.1038/srep26739 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Yu
Li, Fei
Shan, Tong-Ling
Deng, Xutao
Delwart, Eric
Feng, Xi-Ping
A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients
title A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients
title_full A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients
title_fullStr A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients
title_full_unstemmed A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients
title_short A novel species of torque teno mini virus (TTMV) in gingival tissue from chronic periodontitis patients
title_sort novel species of torque teno mini virus (ttmv) in gingival tissue from chronic periodontitis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879676/
https://www.ncbi.nlm.nih.gov/pubmed/27221159
http://dx.doi.org/10.1038/srep26739
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