Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells

B-Raf inhibitors have been used for the treatment of some B-Raf–mutated cancers. They effectively inhibit B-Raf/MEK/ERK signaling in cancers harboring mutant B-Raf, but paradoxically activates MEK/ERK in Ras-mutated cancers. Death receptor 5 (DR5), a cell surface pro-apoptotic protein, triggers apop...

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Detalles Bibliográficos
Autores principales: Oh, You-Take, Deng, Jiusheng, Yue, Ping, Sun, Shi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879700/
https://www.ncbi.nlm.nih.gov/pubmed/27222248
http://dx.doi.org/10.1038/srep26803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879700/
https://www.ncbi.nlm.nih.gov/pubmed/27222248
http://dx.doi.org/10.1038/srep26803

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