Intraperitoneally administered IgG from patients with amyotrophic lateral sclerosis or from an immune-mediated goat model increase the levels of TNF-α, IL-6, and IL-10 in the spinal cord and serum of mice

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that involves the selective loss of the upper and lower motor neurons (MNs). Neuroinflammation has been implicated in the pathogenesis of the sporadic form of the disease. We earlier developed immune-mediated animal model...

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Detalles Bibliográficos
Autores principales: Obál, Izabella, Klausz, Gergely, Mándi, Yvette, Deli, Mária, Siklós, László, Engelhardt, József I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879728/
https://www.ncbi.nlm.nih.gov/pubmed/27220674
http://dx.doi.org/10.1186/s12974-016-0586-7

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