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Cancer stem cell metabolism
Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cel...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879746/ https://www.ncbi.nlm.nih.gov/pubmed/27220421 http://dx.doi.org/10.1186/s13058-016-0712-6 |
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author | Peiris-Pagès, Maria Martinez-Outschoorn, Ubaldo E. Pestell, Richard G. Sotgia, Federica Lisanti, Michael P. |
author_facet | Peiris-Pagès, Maria Martinez-Outschoorn, Ubaldo E. Pestell, Richard G. Sotgia, Federica Lisanti, Michael P. |
author_sort | Peiris-Pagès, Maria |
collection | PubMed |
description | Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets. |
format | Online Article Text |
id | pubmed-4879746 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48797462016-05-26 Cancer stem cell metabolism Peiris-Pagès, Maria Martinez-Outschoorn, Ubaldo E. Pestell, Richard G. Sotgia, Federica Lisanti, Michael P. Breast Cancer Res Review Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets. BioMed Central 2016-05-24 2016 /pmc/articles/PMC4879746/ /pubmed/27220421 http://dx.doi.org/10.1186/s13058-016-0712-6 Text en © Peiris-Pagès et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Peiris-Pagès, Maria Martinez-Outschoorn, Ubaldo E. Pestell, Richard G. Sotgia, Federica Lisanti, Michael P. Cancer stem cell metabolism |
title | Cancer stem cell metabolism |
title_full | Cancer stem cell metabolism |
title_fullStr | Cancer stem cell metabolism |
title_full_unstemmed | Cancer stem cell metabolism |
title_short | Cancer stem cell metabolism |
title_sort | cancer stem cell metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879746/ https://www.ncbi.nlm.nih.gov/pubmed/27220421 http://dx.doi.org/10.1186/s13058-016-0712-6 |
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