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Cancer stem cell metabolism

Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cel...

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Autores principales: Peiris-Pagès, Maria, Martinez-Outschoorn, Ubaldo E., Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879746/
https://www.ncbi.nlm.nih.gov/pubmed/27220421
http://dx.doi.org/10.1186/s13058-016-0712-6
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author Peiris-Pagès, Maria
Martinez-Outschoorn, Ubaldo E.
Pestell, Richard G.
Sotgia, Federica
Lisanti, Michael P.
author_facet Peiris-Pagès, Maria
Martinez-Outschoorn, Ubaldo E.
Pestell, Richard G.
Sotgia, Federica
Lisanti, Michael P.
author_sort Peiris-Pagès, Maria
collection PubMed
description Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets.
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spelling pubmed-48797462016-05-26 Cancer stem cell metabolism Peiris-Pagès, Maria Martinez-Outschoorn, Ubaldo E. Pestell, Richard G. Sotgia, Federica Lisanti, Michael P. Breast Cancer Res Review Cancer is now viewed as a stem cell disease. There is still no consensus on the metabolic characteristics of cancer stem cells, with several studies indicating that they are mainly glycolytic and others pointing instead to mitochondrial metabolism as their principal source of energy. Cancer stem cells also seem to adapt their metabolism to microenvironmental changes by conveniently shifting energy production from one pathway to another, or by acquiring intermediate metabolic phenotypes. Determining the role of cancer stem cell metabolism in carcinogenesis has become a major focus in cancer research, and substantial efforts are conducted towards discovering clinical targets. BioMed Central 2016-05-24 2016 /pmc/articles/PMC4879746/ /pubmed/27220421 http://dx.doi.org/10.1186/s13058-016-0712-6 Text en © Peiris-Pagès et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Peiris-Pagès, Maria
Martinez-Outschoorn, Ubaldo E.
Pestell, Richard G.
Sotgia, Federica
Lisanti, Michael P.
Cancer stem cell metabolism
title Cancer stem cell metabolism
title_full Cancer stem cell metabolism
title_fullStr Cancer stem cell metabolism
title_full_unstemmed Cancer stem cell metabolism
title_short Cancer stem cell metabolism
title_sort cancer stem cell metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879746/
https://www.ncbi.nlm.nih.gov/pubmed/27220421
http://dx.doi.org/10.1186/s13058-016-0712-6
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