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Glycated Albumin Predicts Long-term Survival in Patients Undergoing Hemodialysis

Background: In patients with advanced renal dysfunction undergoing maintenance hemodialysis, glycated albumin (GA) levels may be more representative of blood glucose levels than hemoglobin A1C levels. The aim of this study was to determine the predictive power of GA levels on long-term survival in h...

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Autores principales: Lu, Chien-Lin, Ma, Wen-Ya, Lin, Yuh-Feng, Shyu, Jia-Fwu, Wang, Yuan-Hung, Liu, Yueh-Min, Wu, Chia-Chao, Lu, Kuo-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879771/
https://www.ncbi.nlm.nih.gov/pubmed/27226780
http://dx.doi.org/10.7150/ijms.14259
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author Lu, Chien-Lin
Ma, Wen-Ya
Lin, Yuh-Feng
Shyu, Jia-Fwu
Wang, Yuan-Hung
Liu, Yueh-Min
Wu, Chia-Chao
Lu, Kuo-Cheng
author_facet Lu, Chien-Lin
Ma, Wen-Ya
Lin, Yuh-Feng
Shyu, Jia-Fwu
Wang, Yuan-Hung
Liu, Yueh-Min
Wu, Chia-Chao
Lu, Kuo-Cheng
author_sort Lu, Chien-Lin
collection PubMed
description Background: In patients with advanced renal dysfunction undergoing maintenance hemodialysis, glycated albumin (GA) levels may be more representative of blood glucose levels than hemoglobin A1C levels. The aim of this study was to determine the predictive power of GA levels on long-term survival in hemodialysis patients. Methods: A total of 176 patients with a mean age of 68.2 years were enrolled. The median duration of follow-up was 51.0 months. Receiver-operating characteristic curve analysis was utilized to determine the optimal cutoff value. We examined the cumulative survival rate by Kaplan-Meier estimates and the influence of known survival factors with the multivariate Cox proportional-hazard regression model. Results: In the whole patient group, cumulative survival in the low GA group was better than in the high GA group (p=0.030), with more prominence in those aged <70 years (p=0.029). In subgroup analysis, both diabetic (DM) and non-DM patients with low GA had a better cumulative survival compared with those with high GA. The risk of mortality increased by 3.0% for each 1% increase in serum GA level in all patients undergoing hemodialysis. Conclusions: In addition to serving as a glycemic control marker, GA levels may be useful for evaluating the risk of death in both DM and non-DM patients on hemodialysis.
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spelling pubmed-48797712016-05-25 Glycated Albumin Predicts Long-term Survival in Patients Undergoing Hemodialysis Lu, Chien-Lin Ma, Wen-Ya Lin, Yuh-Feng Shyu, Jia-Fwu Wang, Yuan-Hung Liu, Yueh-Min Wu, Chia-Chao Lu, Kuo-Cheng Int J Med Sci Research Paper Background: In patients with advanced renal dysfunction undergoing maintenance hemodialysis, glycated albumin (GA) levels may be more representative of blood glucose levels than hemoglobin A1C levels. The aim of this study was to determine the predictive power of GA levels on long-term survival in hemodialysis patients. Methods: A total of 176 patients with a mean age of 68.2 years were enrolled. The median duration of follow-up was 51.0 months. Receiver-operating characteristic curve analysis was utilized to determine the optimal cutoff value. We examined the cumulative survival rate by Kaplan-Meier estimates and the influence of known survival factors with the multivariate Cox proportional-hazard regression model. Results: In the whole patient group, cumulative survival in the low GA group was better than in the high GA group (p=0.030), with more prominence in those aged <70 years (p=0.029). In subgroup analysis, both diabetic (DM) and non-DM patients with low GA had a better cumulative survival compared with those with high GA. The risk of mortality increased by 3.0% for each 1% increase in serum GA level in all patients undergoing hemodialysis. Conclusions: In addition to serving as a glycemic control marker, GA levels may be useful for evaluating the risk of death in both DM and non-DM patients on hemodialysis. Ivyspring International Publisher 2016-05-10 /pmc/articles/PMC4879771/ /pubmed/27226780 http://dx.doi.org/10.7150/ijms.14259 Text en © Ivyspring International Publisher. Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. See http://ivyspring.com/terms for terms and conditions.
spellingShingle Research Paper
Lu, Chien-Lin
Ma, Wen-Ya
Lin, Yuh-Feng
Shyu, Jia-Fwu
Wang, Yuan-Hung
Liu, Yueh-Min
Wu, Chia-Chao
Lu, Kuo-Cheng
Glycated Albumin Predicts Long-term Survival in Patients Undergoing Hemodialysis
title Glycated Albumin Predicts Long-term Survival in Patients Undergoing Hemodialysis
title_full Glycated Albumin Predicts Long-term Survival in Patients Undergoing Hemodialysis
title_fullStr Glycated Albumin Predicts Long-term Survival in Patients Undergoing Hemodialysis
title_full_unstemmed Glycated Albumin Predicts Long-term Survival in Patients Undergoing Hemodialysis
title_short Glycated Albumin Predicts Long-term Survival in Patients Undergoing Hemodialysis
title_sort glycated albumin predicts long-term survival in patients undergoing hemodialysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879771/
https://www.ncbi.nlm.nih.gov/pubmed/27226780
http://dx.doi.org/10.7150/ijms.14259
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