Cargando…
Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer
Analysis of extracellular vesicles (EV) and their contents may be useful as disease biomarkers if they reflect the contents of cells of origin, differ between normal and diseased tissue and can be reliably detected. An increasing number of long noncoding RNA (lncRNA) are being reported to be aberran...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880007/ https://www.ncbi.nlm.nih.gov/pubmed/26634812 http://dx.doi.org/10.1093/bfgp/elv058 |
_version_ | 1782433751362437120 |
---|---|
author | Mohankumar, Swathi Patel, Tushar |
author_facet | Mohankumar, Swathi Patel, Tushar |
author_sort | Mohankumar, Swathi |
collection | PubMed |
description | Analysis of extracellular vesicles (EV) and their contents may be useful as disease biomarkers if they reflect the contents of cells of origin, differ between normal and diseased tissue and can be reliably detected. An increasing number of long noncoding RNA (lncRNA) are being reported to be aberrantly expressed in human cancers. These tumor-associated lncRNA may have potential as new biomarkers of disease. In this review, we highlight lncRNAs that are commonly associated with hepatocellular cancer, and summarize their potential biological roles and underlying molecular mechanisms. While lncRNA can be detected in the circulation, their low expression within circulating vesicles will require the use of highly sensitive detection technologies such as digital polymerase chain reaction or next-generation sequencing. While the integrity and functional role of tumor-specific lncRNAs within EV have yet to be established, their presence or enrichment within tumor cell-derived EV offers promise for their potential as disease biomarkers. |
format | Online Article Text |
id | pubmed-4880007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48800072016-05-31 Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer Mohankumar, Swathi Patel, Tushar Brief Funct Genomics Papers Analysis of extracellular vesicles (EV) and their contents may be useful as disease biomarkers if they reflect the contents of cells of origin, differ between normal and diseased tissue and can be reliably detected. An increasing number of long noncoding RNA (lncRNA) are being reported to be aberrantly expressed in human cancers. These tumor-associated lncRNA may have potential as new biomarkers of disease. In this review, we highlight lncRNAs that are commonly associated with hepatocellular cancer, and summarize their potential biological roles and underlying molecular mechanisms. While lncRNA can be detected in the circulation, their low expression within circulating vesicles will require the use of highly sensitive detection technologies such as digital polymerase chain reaction or next-generation sequencing. While the integrity and functional role of tumor-specific lncRNAs within EV have yet to be established, their presence or enrichment within tumor cell-derived EV offers promise for their potential as disease biomarkers. Oxford University Press 2016-05 2015-12-03 /pmc/articles/PMC4880007/ /pubmed/26634812 http://dx.doi.org/10.1093/bfgp/elv058 Text en © The Author 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Papers Mohankumar, Swathi Patel, Tushar Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer |
title | Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer |
title_full | Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer |
title_fullStr | Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer |
title_full_unstemmed | Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer |
title_short | Extracellular vesicle long noncoding RNA as potential biomarkers of liver cancer |
title_sort | extracellular vesicle long noncoding rna as potential biomarkers of liver cancer |
topic | Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880007/ https://www.ncbi.nlm.nih.gov/pubmed/26634812 http://dx.doi.org/10.1093/bfgp/elv058 |
work_keys_str_mv | AT mohankumarswathi extracellularvesiclelongnoncodingrnaaspotentialbiomarkersoflivercancer AT pateltushar extracellularvesiclelongnoncodingrnaaspotentialbiomarkersoflivercancer |