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Novel Hypomorphic Alleles of the Mouse Tyrosinase Gene Induced by CRISPR-Cas9 Nucleases Cause Non-Albino Pigmentation Phenotypes

Tyrosinase is a key enzyme in melanin biosynthesis. Mutations in the gene encoding tyrosinase (Tyr) cause oculocutaneous albinism (OCA1) in humans. Alleles of the Tyr gene have been useful in studying pigment biology and coat color formation. Over 100 different Tyr alleles have been reported in mice...

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Detalles Bibliográficos
Autores principales:	Challa, Anil K., Boitet, Evan R., Turner, Ashley N., Johnson, Larry W., Kennedy, Daniel, Downs, Ethan R., Hymel, Katherine M., Gross, Alecia K., Kesterson, Robert A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880214/ https://www.ncbi.nlm.nih.gov/pubmed/27224051 http://dx.doi.org/10.1371/journal.pone.0155812

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