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Type I Interferons Direct Gammaherpesvirus Host Colonization

Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host defences, and type I interferons (IFN-I) limit infection while viral evasion promotes it. To understand how IFN-I and it...

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Detalles Bibliográficos
Autores principales: Tan, Cindy S. E., Lawler, Clara, May, Janet S., Belz, Gabrielle T., Stevenson, Philip G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880296/
https://www.ncbi.nlm.nih.gov/pubmed/27223694
http://dx.doi.org/10.1371/journal.ppat.1005654