Small Molecule APY606 Displays Extensive Antitumor Activity in Pancreatic Cancer via Impairing Ras-MAPK Signaling

Pancreatic cancer has been found with abnormal expression or mutation in Ras proteins. Oncogenic Ras activation exploits their extensive signaling reach to affect multiple cellular processes, in which the mitogen-activated protein kinase (MAPK) signaling exerts important roles in tumorigenesis. Ther...

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Detalles Bibliográficos
Autores principales: Guo, Na, Liu, Zuojia, Zhao, Wenjing, Wang, Erkang, Wang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880342/
https://www.ncbi.nlm.nih.gov/pubmed/27223122
http://dx.doi.org/10.1371/journal.pone.0155874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880342/
https://www.ncbi.nlm.nih.gov/pubmed/27223122
http://dx.doi.org/10.1371/journal.pone.0155874

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