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Apoptosis deregulation in myeloproliferative neoplasms
Philadelphia-chromosome negative chronic myeloproliferative neoplasms are clonal hematologic diseases characterized by hematopoietic progenitor independence from or hypersensitivity to cytokines. The cellular and molecular mechanisms involved in the pathophysiology of myeloproliferative neoplasms ha...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880398/ https://www.ncbi.nlm.nih.gov/pubmed/24488400 http://dx.doi.org/10.1590/S1679-45082013000400025 |
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author | Tognon, Raquel Nunes, Natália de Souza de Castro, Fabíola Attié |
author_facet | Tognon, Raquel Nunes, Natália de Souza de Castro, Fabíola Attié |
author_sort | Tognon, Raquel |
collection | PubMed |
description | Philadelphia-chromosome negative chronic myeloproliferative neoplasms are clonal hematologic diseases characterized by hematopoietic progenitor independence from or hypersensitivity to cytokines. The cellular and molecular mechanisms involved in the pathophysiology of myeloproliferative neoplasms have not yet been fully clarified. Pathophysiologic findings relevant for myeloproliferative neoplasms are associated with genetic alterations, such as, somatic mutation in the gene that codifies JAK-2 (JAK V617F). Deregulation of the process of programmed cellular death, called apoptosis, seems to participate in the pathogenesis of these disorders. It is known that expression deregulation of pro- and anti-apoptotic genes promotes cell resistance to apoptosis, culminating with the accumulation of myeloid cells and establishing neoplasms. This review will focus on the alterations in apoptosis regulation in myeloproliferative neoplasms, and the importance of a better understanding of this mechanism for the development of new therapies for these diseases. |
format | Online Article Text |
id | pubmed-4880398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
record_format | MEDLINE/PubMed |
spelling | pubmed-48803982016-08-10 Apoptosis deregulation in myeloproliferative neoplasms Tognon, Raquel Nunes, Natália de Souza de Castro, Fabíola Attié Einstein (Sao Paulo) Reviewing Basic sciences Philadelphia-chromosome negative chronic myeloproliferative neoplasms are clonal hematologic diseases characterized by hematopoietic progenitor independence from or hypersensitivity to cytokines. The cellular and molecular mechanisms involved in the pathophysiology of myeloproliferative neoplasms have not yet been fully clarified. Pathophysiologic findings relevant for myeloproliferative neoplasms are associated with genetic alterations, such as, somatic mutation in the gene that codifies JAK-2 (JAK V617F). Deregulation of the process of programmed cellular death, called apoptosis, seems to participate in the pathogenesis of these disorders. It is known that expression deregulation of pro- and anti-apoptotic genes promotes cell resistance to apoptosis, culminating with the accumulation of myeloid cells and establishing neoplasms. This review will focus on the alterations in apoptosis regulation in myeloproliferative neoplasms, and the importance of a better understanding of this mechanism for the development of new therapies for these diseases. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2013 /pmc/articles/PMC4880398/ /pubmed/24488400 http://dx.doi.org/10.1590/S1679-45082013000400025 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviewing Basic sciences Tognon, Raquel Nunes, Natália de Souza de Castro, Fabíola Attié Apoptosis deregulation in myeloproliferative neoplasms |
title | Apoptosis deregulation in myeloproliferative neoplasms |
title_full | Apoptosis deregulation in myeloproliferative neoplasms |
title_fullStr | Apoptosis deregulation in myeloproliferative neoplasms |
title_full_unstemmed | Apoptosis deregulation in myeloproliferative neoplasms |
title_short | Apoptosis deregulation in myeloproliferative neoplasms |
title_sort | apoptosis deregulation in myeloproliferative neoplasms |
topic | Reviewing Basic sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880398/ https://www.ncbi.nlm.nih.gov/pubmed/24488400 http://dx.doi.org/10.1590/S1679-45082013000400025 |
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