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Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries

BACKGROUND: The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was established in 2008 to answer strategic questions about schistosomiasis control. For programme managers, a high-priority question is: what are the most cost-effective strategies for delivering preventive c...

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Autores principales: Ezeamama, Amara E., He, Chun-La, Shen, Ye, Yin, Xiao-Ping, Binder, Sue C., Campbell, Carl H., Rathbun, Stephen, Whalen, Christopher C., N’Goran, Eliézer K., Utzinger, Jürg, Olsen, Annette, Magnussen, Pascal, Kinung’hi, Safari, Fenwick, Alan, Phillips, Anna, Ferro, Josefo, Karanja, Diana M. S., Mwinzi, Pauline N. M., Montgomery, Susan, Secor, W. Evan, Hamidou, Amina, Garba, Amadou, King, Charles H., Colley, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880878/
https://www.ncbi.nlm.nih.gov/pubmed/27230666
http://dx.doi.org/10.1186/s12879-016-1575-2
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author Ezeamama, Amara E.
He, Chun-La
Shen, Ye
Yin, Xiao-Ping
Binder, Sue C.
Campbell, Carl H.
Rathbun, Stephen
Whalen, Christopher C.
N’Goran, Eliézer K.
Utzinger, Jürg
Olsen, Annette
Magnussen, Pascal
Kinung’hi, Safari
Fenwick, Alan
Phillips, Anna
Ferro, Josefo
Karanja, Diana M. S.
Mwinzi, Pauline N. M.
Montgomery, Susan
Secor, W. Evan
Hamidou, Amina
Garba, Amadou
King, Charles H.
Colley, Daniel G.
author_facet Ezeamama, Amara E.
He, Chun-La
Shen, Ye
Yin, Xiao-Ping
Binder, Sue C.
Campbell, Carl H.
Rathbun, Stephen
Whalen, Christopher C.
N’Goran, Eliézer K.
Utzinger, Jürg
Olsen, Annette
Magnussen, Pascal
Kinung’hi, Safari
Fenwick, Alan
Phillips, Anna
Ferro, Josefo
Karanja, Diana M. S.
Mwinzi, Pauline N. M.
Montgomery, Susan
Secor, W. Evan
Hamidou, Amina
Garba, Amadou
King, Charles H.
Colley, Daniel G.
author_sort Ezeamama, Amara E.
collection PubMed
description BACKGROUND: The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was established in 2008 to answer strategic questions about schistosomiasis control. For programme managers, a high-priority question is: what are the most cost-effective strategies for delivering preventive chemotherapy (PCT) with praziquantel (PZQ)? This paper describes the process SCORE used to transform this question into a harmonized research protocol, the study design for answering this question, the village eligibility assessments and data resulting from the first year of the study. METHODS: Beginning in 2009, SCORE held a series of meetings to specify empirical questions and design studies related to different schedules of PCT for schistosomiasis control in communities with high (gaining control studies) and moderate (sustaining control studies) prevalence of Schistosoma infection among school-aged children. Seven studies are currently being implemented in five African countries. During the first year, villages were screened for eligibility, and data were collected on prevalence and intensity of infection prior to randomisation and the implementation of different schemes of PZQ intervention strategies. RESULTS: These studies of different treatment schedules with PZQ will provide the most comprehensive data thus far on the optimal frequency and continuity of PCT for schistosomiasis infection and morbidity control. CONCLUSIONS: We expect that the study outcomes will provide data for decision-making for country programme managers and a rich resource of information to the schistosomiasis research community. TRIAL REGISTRATION: The trials are registered at International Standard Randomised Controlled Trial registry (identifiers: ISRCTN99401114, ISRCTN14849830, ISRCTN16755535, ISRCTN14117624, ISRCTN95819193 and ISRCTN32045736).
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spelling pubmed-48808782016-06-07 Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries Ezeamama, Amara E. He, Chun-La Shen, Ye Yin, Xiao-Ping Binder, Sue C. Campbell, Carl H. Rathbun, Stephen Whalen, Christopher C. N’Goran, Eliézer K. Utzinger, Jürg Olsen, Annette Magnussen, Pascal Kinung’hi, Safari Fenwick, Alan Phillips, Anna Ferro, Josefo Karanja, Diana M. S. Mwinzi, Pauline N. M. Montgomery, Susan Secor, W. Evan Hamidou, Amina Garba, Amadou King, Charles H. Colley, Daniel G. BMC Infect Dis Research Article BACKGROUND: The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was established in 2008 to answer strategic questions about schistosomiasis control. For programme managers, a high-priority question is: what are the most cost-effective strategies for delivering preventive chemotherapy (PCT) with praziquantel (PZQ)? This paper describes the process SCORE used to transform this question into a harmonized research protocol, the study design for answering this question, the village eligibility assessments and data resulting from the first year of the study. METHODS: Beginning in 2009, SCORE held a series of meetings to specify empirical questions and design studies related to different schedules of PCT for schistosomiasis control in communities with high (gaining control studies) and moderate (sustaining control studies) prevalence of Schistosoma infection among school-aged children. Seven studies are currently being implemented in five African countries. During the first year, villages were screened for eligibility, and data were collected on prevalence and intensity of infection prior to randomisation and the implementation of different schemes of PZQ intervention strategies. RESULTS: These studies of different treatment schedules with PZQ will provide the most comprehensive data thus far on the optimal frequency and continuity of PCT for schistosomiasis infection and morbidity control. CONCLUSIONS: We expect that the study outcomes will provide data for decision-making for country programme managers and a rich resource of information to the schistosomiasis research community. TRIAL REGISTRATION: The trials are registered at International Standard Randomised Controlled Trial registry (identifiers: ISRCTN99401114, ISRCTN14849830, ISRCTN16755535, ISRCTN14117624, ISRCTN95819193 and ISRCTN32045736). BioMed Central 2016-05-26 /pmc/articles/PMC4880878/ /pubmed/27230666 http://dx.doi.org/10.1186/s12879-016-1575-2 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ezeamama, Amara E.
He, Chun-La
Shen, Ye
Yin, Xiao-Ping
Binder, Sue C.
Campbell, Carl H.
Rathbun, Stephen
Whalen, Christopher C.
N’Goran, Eliézer K.
Utzinger, Jürg
Olsen, Annette
Magnussen, Pascal
Kinung’hi, Safari
Fenwick, Alan
Phillips, Anna
Ferro, Josefo
Karanja, Diana M. S.
Mwinzi, Pauline N. M.
Montgomery, Susan
Secor, W. Evan
Hamidou, Amina
Garba, Amadou
King, Charles H.
Colley, Daniel G.
Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries
title Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries
title_full Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries
title_fullStr Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries
title_full_unstemmed Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries
title_short Gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five African countries
title_sort gaining and sustaining schistosomiasis control: study protocol and baseline data prior to different treatment strategies in five african countries
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880878/
https://www.ncbi.nlm.nih.gov/pubmed/27230666
http://dx.doi.org/10.1186/s12879-016-1575-2
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