Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report

BACKGROUND: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects. CASE PRESENTATION: We present a case study of a patient with schizoaffective dis...

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Autores principales: Matsuura, Hiroki, Kimoto, Sohei, Harada, Izumi, Naemura, Satoshi, Yamamuro, Kazuhiko, Kishimoto, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880967/
https://www.ncbi.nlm.nih.gov/pubmed/27229149
http://dx.doi.org/10.1186/s12888-016-0874-x
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author Matsuura, Hiroki
Kimoto, Sohei
Harada, Izumi
Naemura, Satoshi
Yamamuro, Kazuhiko
Kishimoto, Toshifumi
author_facet Matsuura, Hiroki
Kimoto, Sohei
Harada, Izumi
Naemura, Satoshi
Yamamuro, Kazuhiko
Kishimoto, Toshifumi
author_sort Matsuura, Hiroki
collection PubMed
description BACKGROUND: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects. CASE PRESENTATION: We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms. CONCLUSION: The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.
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spelling pubmed-48809672016-05-27 Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report Matsuura, Hiroki Kimoto, Sohei Harada, Izumi Naemura, Satoshi Yamamuro, Kazuhiko Kishimoto, Toshifumi BMC Psychiatry Case Report BACKGROUND: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects. CASE PRESENTATION: We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms. CONCLUSION: The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia. BioMed Central 2016-05-26 /pmc/articles/PMC4880967/ /pubmed/27229149 http://dx.doi.org/10.1186/s12888-016-0874-x Text en © Matsuura et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Matsuura, Hiroki
Kimoto, Sohei
Harada, Izumi
Naemura, Satoshi
Yamamuro, Kazuhiko
Kishimoto, Toshifumi
Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report
title Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report
title_full Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report
title_fullStr Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report
title_full_unstemmed Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report
title_short Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report
title_sort lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880967/
https://www.ncbi.nlm.nih.gov/pubmed/27229149
http://dx.doi.org/10.1186/s12888-016-0874-x
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