Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico

BACKGROUND: Genetic variations of the TCF7L2 gene are associated with the development of Type 2 diabetes (T2D). The associated mutations have demonstrated an adaptive role in some human populations, but no studies have determined the impact of evolutionary forces on genetic diversity in indigenous p...

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Detalles Bibliográficos
Autores principales: Acosta, Jose Luis, Hernández-Mondragón, Alma Cristal, Correa-Acosta, Laura Carolina, Cazañas-Padilla, Sandra Nathaly, Chávez-Florencio, Berenice, Ramírez-Vega, Elvia Yamilet, Monge-Cázares, Tulia, Aguilar-Salinas, Carlos A., Tusié-Luna, Teresa, del Bosque-Plata, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880969/
https://www.ncbi.nlm.nih.gov/pubmed/27230431
http://dx.doi.org/10.1186/s12863-016-0372-7

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