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Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription

The COP9 signalosome has been implicated in pluripotency maintenance of human embryonic stem cells. Yet, the mechanism for the COP9 signalosome to regulate pluripotency remains elusive. Through knocking down individual COP9 subunits, we demonstrate that Cops2, but not the whole COP9 signalosome, is...

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Detalles Bibliográficos
Autores principales:	Zhang, Weiyu, Ni, Peiling, Mou, Chunlin, Zhang, Yanqin, Guo, Hongchao, Zhao, Tong, Loh, Yuin-Han, Chen, Lingyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881025/ https://www.ncbi.nlm.nih.gov/pubmed/27226076 http://dx.doi.org/10.1038/srep26804

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