Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome

PURPOSE: To report a case of Wolfram syndrome (WS) characterized by diabetes mellitus, diabetes insipidus, progressive optic atrophy, and deafness. CASE REPORT: A 19-year-old female patient, a known case of diabetes mellitus type I from six years before, presented with progressive vision loss since...

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Autores principales: Maleki, Nasrollah, Bashardoust, Bahman, Zakeri, Anahita, Salehifar, Azita, Tavosi, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881228/
https://www.ncbi.nlm.nih.gov/pubmed/27239592
http://dx.doi.org/10.1016/j.joco.2015.11.003
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author Maleki, Nasrollah
Bashardoust, Bahman
Zakeri, Anahita
Salehifar, Azita
Tavosi, Zahra
author_facet Maleki, Nasrollah
Bashardoust, Bahman
Zakeri, Anahita
Salehifar, Azita
Tavosi, Zahra
author_sort Maleki, Nasrollah
collection PubMed
description PURPOSE: To report a case of Wolfram syndrome (WS) characterized by diabetes mellitus, diabetes insipidus, progressive optic atrophy, and deafness. CASE REPORT: A 19-year-old female patient, a known case of diabetes mellitus type I from six years before, presented with progressive vision loss since four years earlier. On fundoscopic examination, she had bilateral optic atrophy without diabetic retinopathy. The patient also had diabetes insipidus, neurosensory deafness, and neurogenic bladder. CONCLUSION: WS should be considered a differential diagnosis in patients with diabetes mellitus who present with optic atrophy, and it is necessary to perform a hearing test as well as collecting 24-h urine output.
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spelling pubmed-48812282016-05-27 Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome Maleki, Nasrollah Bashardoust, Bahman Zakeri, Anahita Salehifar, Azita Tavosi, Zahra J Curr Ophthalmol Article PURPOSE: To report a case of Wolfram syndrome (WS) characterized by diabetes mellitus, diabetes insipidus, progressive optic atrophy, and deafness. CASE REPORT: A 19-year-old female patient, a known case of diabetes mellitus type I from six years before, presented with progressive vision loss since four years earlier. On fundoscopic examination, she had bilateral optic atrophy without diabetic retinopathy. The patient also had diabetes insipidus, neurosensory deafness, and neurogenic bladder. CONCLUSION: WS should be considered a differential diagnosis in patients with diabetes mellitus who present with optic atrophy, and it is necessary to perform a hearing test as well as collecting 24-h urine output. Elsevier 2016-01-02 /pmc/articles/PMC4881228/ /pubmed/27239592 http://dx.doi.org/10.1016/j.joco.2015.11.003 Text en Copyright © 2015, Iranian Society of Ophthalmology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Maleki, Nasrollah
Bashardoust, Bahman
Zakeri, Anahita
Salehifar, Azita
Tavosi, Zahra
Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome
title Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome
title_full Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome
title_fullStr Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome
title_full_unstemmed Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome
title_short Diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: A case of Wolfram (DIDMOAD) syndrome
title_sort diabetes mellitus, diabetes insipidus, optic atrophy, and deafness: a case of wolfram (didmoad) syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881228/
https://www.ncbi.nlm.nih.gov/pubmed/27239592
http://dx.doi.org/10.1016/j.joco.2015.11.003
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