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A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines
The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881492/ https://www.ncbi.nlm.nih.gov/pubmed/27153063 http://dx.doi.org/10.3390/ijms17050666 |
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author | Nandy, Ashesh Basak, Subhash C. |
author_facet | Nandy, Ashesh Basak, Subhash C. |
author_sort | Nandy, Ashesh |
collection | PubMed |
description | The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise of multi-valent dosages. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development. |
format | Online Article Text |
id | pubmed-4881492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48814922016-05-27 A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines Nandy, Ashesh Basak, Subhash C. Int J Mol Sci Review The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise of multi-valent dosages. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development. MDPI 2016-05-04 /pmc/articles/PMC4881492/ /pubmed/27153063 http://dx.doi.org/10.3390/ijms17050666 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nandy, Ashesh Basak, Subhash C. A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines |
title | A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines |
title_full | A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines |
title_fullStr | A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines |
title_full_unstemmed | A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines |
title_short | A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines |
title_sort | brief review of computer-assisted approaches to rational design of peptide vaccines |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881492/ https://www.ncbi.nlm.nih.gov/pubmed/27153063 http://dx.doi.org/10.3390/ijms17050666 |
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