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A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines

The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines...

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Detalles Bibliográficos
Autores principales: Nandy, Ashesh, Basak, Subhash C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881492/
https://www.ncbi.nlm.nih.gov/pubmed/27153063
http://dx.doi.org/10.3390/ijms17050666
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author Nandy, Ashesh
Basak, Subhash C.
author_facet Nandy, Ashesh
Basak, Subhash C.
author_sort Nandy, Ashesh
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description The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise of multi-valent dosages. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development.
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spelling pubmed-48814922016-05-27 A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines Nandy, Ashesh Basak, Subhash C. Int J Mol Sci Review The growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. Given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. Peptide vaccines have, over the last several years, begun to be looked on as more appropriate alternatives, which are economically affordable, require less time for development and hold the promise of multi-valent dosages. The developments in bioinformatics, proteomics, immunogenomics, structural biology and other sciences have spurred the growth of vaccinomics where computer assisted approaches serve to identify suitable peptide targets for eventual development of vaccines. In this mini-review we give a brief overview of some of the recent trends in computer assisted vaccine development with emphasis on the primary selection procedures of probable peptide candidates for vaccine development. MDPI 2016-05-04 /pmc/articles/PMC4881492/ /pubmed/27153063 http://dx.doi.org/10.3390/ijms17050666 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nandy, Ashesh
Basak, Subhash C.
A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines
title A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines
title_full A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines
title_fullStr A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines
title_full_unstemmed A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines
title_short A Brief Review of Computer-Assisted Approaches to Rational Design of Peptide Vaccines
title_sort brief review of computer-assisted approaches to rational design of peptide vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881492/
https://www.ncbi.nlm.nih.gov/pubmed/27153063
http://dx.doi.org/10.3390/ijms17050666
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