Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells

Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activa...

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Detalles Bibliográficos
Autores principales: Huang, Shiow-Chyn, Kuo, Ping-Chung, Hung, Hsin-Yi, Pan, Tai-Long, Chen, Fu-An, Wu, Tian-Shung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881507/
https://www.ncbi.nlm.nih.gov/pubmed/27164091
http://dx.doi.org/10.3390/ijms17050681
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author Huang, Shiow-Chyn
Kuo, Ping-Chung
Hung, Hsin-Yi
Pan, Tai-Long
Chen, Fu-An
Wu, Tian-Shung
author_facet Huang, Shiow-Chyn
Kuo, Ping-Chung
Hung, Hsin-Yi
Pan, Tai-Long
Chen, Fu-An
Wu, Tian-Shung
author_sort Huang, Shiow-Chyn
collection PubMed
description Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.
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spelling pubmed-48815072016-05-27 Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells Huang, Shiow-Chyn Kuo, Ping-Chung Hung, Hsin-Yi Pan, Tai-Long Chen, Fu-An Wu, Tian-Shung Int J Mol Sci Letter Three new γ-ionylideneacetic acid derivatives, phellinulins A–C (1–3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis. MDPI 2016-05-06 /pmc/articles/PMC4881507/ /pubmed/27164091 http://dx.doi.org/10.3390/ijms17050681 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Letter
Huang, Shiow-Chyn
Kuo, Ping-Chung
Hung, Hsin-Yi
Pan, Tai-Long
Chen, Fu-An
Wu, Tian-Shung
Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells
title Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells
title_full Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells
title_fullStr Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells
title_full_unstemmed Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells
title_short Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells
title_sort ionone derivatives from the mycelium of phellinus linteus and the inhibitory effect on activated rat hepatic stellate cells
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881507/
https://www.ncbi.nlm.nih.gov/pubmed/27164091
http://dx.doi.org/10.3390/ijms17050681
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