Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract

MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. miR-155 is a multifunctional miRNA with inflammation-related and oncogenic roles. In particular, the dysregulation of miR-155 has been strongly...

Descripción completa

Detalles Bibliográficos
Autores principales: Wan, Jianhua, Xia, Liang, Xu, Wenting, Lu, Nonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881531/
https://www.ncbi.nlm.nih.gov/pubmed/27187359
http://dx.doi.org/10.3390/ijms17050709
_version_ 1782433978906574848
author Wan, Jianhua
Xia, Liang
Xu, Wenting
Lu, Nonghua
author_facet Wan, Jianhua
Xia, Liang
Xu, Wenting
Lu, Nonghua
author_sort Wan, Jianhua
collection PubMed
description MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. miR-155 is a multifunctional miRNA with inflammation-related and oncogenic roles. In particular, the dysregulation of miR-155 has been strongly implicated in Helicobacter pylori-related gastric disease, inflammatory bowel disease, and colorectal cancer in addition to being involved in molecular changes of important targets and signaling pathways. This review focuses on the expression and function of miR-155 during inflammation and carcinogenesis and its potential use as an effective therapeutic target for certain gastrointestinal diseases.
format Online
Article
Text
id pubmed-4881531
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-48815312016-05-27 Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract Wan, Jianhua Xia, Liang Xu, Wenting Lu, Nonghua Int J Mol Sci Review MicroRNAs (miRNAs) are a type of small noncoding RNA that can regulate the expression of target genes under physiological and pathophysiological conditions. miR-155 is a multifunctional miRNA with inflammation-related and oncogenic roles. In particular, the dysregulation of miR-155 has been strongly implicated in Helicobacter pylori-related gastric disease, inflammatory bowel disease, and colorectal cancer in addition to being involved in molecular changes of important targets and signaling pathways. This review focuses on the expression and function of miR-155 during inflammation and carcinogenesis and its potential use as an effective therapeutic target for certain gastrointestinal diseases. MDPI 2016-05-11 /pmc/articles/PMC4881531/ /pubmed/27187359 http://dx.doi.org/10.3390/ijms17050709 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wan, Jianhua
Xia, Liang
Xu, Wenting
Lu, Nonghua
Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract
title Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract
title_full Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract
title_fullStr Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract
title_full_unstemmed Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract
title_short Expression and Function of miR-155 in Diseases of the Gastrointestinal Tract
title_sort expression and function of mir-155 in diseases of the gastrointestinal tract
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881531/
https://www.ncbi.nlm.nih.gov/pubmed/27187359
http://dx.doi.org/10.3390/ijms17050709
work_keys_str_mv AT wanjianhua expressionandfunctionofmir155indiseasesofthegastrointestinaltract
AT xialiang expressionandfunctionofmir155indiseasesofthegastrointestinaltract
AT xuwenting expressionandfunctionofmir155indiseasesofthegastrointestinaltract
AT lunonghua expressionandfunctionofmir155indiseasesofthegastrointestinaltract

Ejemplares similares