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Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients

Kawasaki disease (KD) is a type of systemic vasculitis that primarily affects children under the age of five years old. For sufferers of KD, intravenous immunoglobulin (IVIG) has been found to successfully diminish the occurrence of coronary artery lesions. Anemia is commonly found in KD patients, a...

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Autores principales: Huang, Ying-Hsien, Kuo, Ho-Chang, Huang, Fu-Chen, Yu, Hong-Ren, Hsieh, Kai-Sheng, Yang, Ya-Ling, Sheen, Jiunn-Ming, Li, Sung-Chou, Kuo, Hsing-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881537/
https://www.ncbi.nlm.nih.gov/pubmed/27187366
http://dx.doi.org/10.3390/ijms17050715
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author Huang, Ying-Hsien
Kuo, Ho-Chang
Huang, Fu-Chen
Yu, Hong-Ren
Hsieh, Kai-Sheng
Yang, Ya-Ling
Sheen, Jiunn-Ming
Li, Sung-Chou
Kuo, Hsing-Chun
author_facet Huang, Ying-Hsien
Kuo, Ho-Chang
Huang, Fu-Chen
Yu, Hong-Ren
Hsieh, Kai-Sheng
Yang, Ya-Ling
Sheen, Jiunn-Ming
Li, Sung-Chou
Kuo, Hsing-Chun
author_sort Huang, Ying-Hsien
collection PubMed
description Kawasaki disease (KD) is a type of systemic vasculitis that primarily affects children under the age of five years old. For sufferers of KD, intravenous immunoglobulin (IVIG) has been found to successfully diminish the occurrence of coronary artery lesions. Anemia is commonly found in KD patients, and we have shown that in appropriately elevated hepcidin levels are related to decreased hemoglobin levels in these patients. In this study, we investigated the time period of anemia and iron metabolism during different stages of KD. A total of 100 patients with KD and 20 control subjects were enrolled in this study for red blood cell and hemoglobin analysis. Furthermore, plasma, urine hepcidin, and plasma IL-6 levels were evaluated using enzyme-linked immunosorbent assay in 20 KD patients and controls. Changes in hemoglobin, plasma iron levels, and total iron binding capacity (TIBC) were also measured in patients with KD. Hemoglobin, iron levels, and TIBC were lower (p < 0.001, p = 0.009, and p < 0.001, respectively) while plasma IL-6 and hepcidin levels (both p < 0.001) were higher in patients with KD than in the controls prior to IVIG administration. Moreover, plasma hepcidin levels were positively and significantly correlated with urine hepcidin levels (p < 0.001) prior to IVIG administration. After IVIG treatment, plasma hepcidin and hemoglobin levels significantly decreased (both p < 0.001). Of particular note was a subsequent gradual increase in hemoglobin levels during the three weeks after IVIG treatment; nevertheless, the hemoglobin levels stayed lower in KD patients than in the controls (p = 0.045). These findings provide a longitudinal study of hemoglobin changes and among the first evidence that hepcidin induces transient anemia and hypoferremia during KD’s acute inflammatory phase.
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spelling pubmed-48815372016-05-27 Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients Huang, Ying-Hsien Kuo, Ho-Chang Huang, Fu-Chen Yu, Hong-Ren Hsieh, Kai-Sheng Yang, Ya-Ling Sheen, Jiunn-Ming Li, Sung-Chou Kuo, Hsing-Chun Int J Mol Sci Article Kawasaki disease (KD) is a type of systemic vasculitis that primarily affects children under the age of five years old. For sufferers of KD, intravenous immunoglobulin (IVIG) has been found to successfully diminish the occurrence of coronary artery lesions. Anemia is commonly found in KD patients, and we have shown that in appropriately elevated hepcidin levels are related to decreased hemoglobin levels in these patients. In this study, we investigated the time period of anemia and iron metabolism during different stages of KD. A total of 100 patients with KD and 20 control subjects were enrolled in this study for red blood cell and hemoglobin analysis. Furthermore, plasma, urine hepcidin, and plasma IL-6 levels were evaluated using enzyme-linked immunosorbent assay in 20 KD patients and controls. Changes in hemoglobin, plasma iron levels, and total iron binding capacity (TIBC) were also measured in patients with KD. Hemoglobin, iron levels, and TIBC were lower (p < 0.001, p = 0.009, and p < 0.001, respectively) while plasma IL-6 and hepcidin levels (both p < 0.001) were higher in patients with KD than in the controls prior to IVIG administration. Moreover, plasma hepcidin levels were positively and significantly correlated with urine hepcidin levels (p < 0.001) prior to IVIG administration. After IVIG treatment, plasma hepcidin and hemoglobin levels significantly decreased (both p < 0.001). Of particular note was a subsequent gradual increase in hemoglobin levels during the three weeks after IVIG treatment; nevertheless, the hemoglobin levels stayed lower in KD patients than in the controls (p = 0.045). These findings provide a longitudinal study of hemoglobin changes and among the first evidence that hepcidin induces transient anemia and hypoferremia during KD’s acute inflammatory phase. MDPI 2016-05-12 /pmc/articles/PMC4881537/ /pubmed/27187366 http://dx.doi.org/10.3390/ijms17050715 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Ying-Hsien
Kuo, Ho-Chang
Huang, Fu-Chen
Yu, Hong-Ren
Hsieh, Kai-Sheng
Yang, Ya-Ling
Sheen, Jiunn-Ming
Li, Sung-Chou
Kuo, Hsing-Chun
Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients
title Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients
title_full Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients
title_fullStr Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients
title_full_unstemmed Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients
title_short Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients
title_sort hepcidin-induced iron deficiency is related to transient anemia and hypoferremia in kawasaki disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881537/
https://www.ncbi.nlm.nih.gov/pubmed/27187366
http://dx.doi.org/10.3390/ijms17050715
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