Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from (177)Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts

Radiolabeled antibodies (mAbs) provide efficient tools for cancer therapy. The combination of low energy β(−)-emissions (500 keV(max); 130 keV(ave)) along with a γ-emission for imaging makes (177)Lu (T(1/2) = 6.7 day) a suitable radionuclide for radioimmunotherapy (RIT) of tumor burdens possibly too...

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Detalles Bibliográficos
Autores principales: Yong, Kwon Joong, Milenic, Diane E., Baidoo, Kwamena E., Brechbiel, Martin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881558/
https://www.ncbi.nlm.nih.gov/pubmed/27196891
http://dx.doi.org/10.3390/ijms17050736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881558/
https://www.ncbi.nlm.nih.gov/pubmed/27196891
http://dx.doi.org/10.3390/ijms17050736

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