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Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis

A human artificial chromosome (HAC) is maintained as an episome within a cell and avoids random integration into the host genome. It can transfer multiple and/or large transgenes along with their regulatory elements thereby resembling native chromosomes. Using this HAC system, we established mesench...

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Detalles Bibliográficos
Autores principales:	Watanabe, Yasuhiro, Kazuki, Yasuhiro, Kazuki, Kanako, Ebiki, Mitsutaka, Nakanishi, Mami, Nakamura, Kazuomi, Yoshida Yamakawa, Miho, Hosokawa, Hiroyuki, Ohbayashi, Tetsuya, Oshimura, Mitsuo, Nakashima, Kenji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881756/ https://www.ncbi.nlm.nih.gov/pubmed/26440597 http://dx.doi.org/10.1038/mtna.2015.28

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