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miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα

MicroRNA-135a (miR-135a) down-modulates parameters of cancer progression and its expression is decreased in metastatic breast cancers (as compared to non-metastatic tumors) as well as in prostate tumors relative to normal tissue. These expression and activity patterns are opposite to those of the Es...

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Autores principales: Tribollet, Violaine, Barenton, Bruno, Kroiss, Auriane, Vincent, Séverine, Zhang, Ling, Forcet, Christelle, Cerutti, Catherine, Périan, Séverine, Allioli, Nathalie, Samarut, Jacques, Vanacker, Jean-Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881992/
https://www.ncbi.nlm.nih.gov/pubmed/27227989
http://dx.doi.org/10.1371/journal.pone.0156445
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author Tribollet, Violaine
Barenton, Bruno
Kroiss, Auriane
Vincent, Séverine
Zhang, Ling
Forcet, Christelle
Cerutti, Catherine
Périan, Séverine
Allioli, Nathalie
Samarut, Jacques
Vanacker, Jean-Marc
author_facet Tribollet, Violaine
Barenton, Bruno
Kroiss, Auriane
Vincent, Séverine
Zhang, Ling
Forcet, Christelle
Cerutti, Catherine
Périan, Séverine
Allioli, Nathalie
Samarut, Jacques
Vanacker, Jean-Marc
author_sort Tribollet, Violaine
collection PubMed
description MicroRNA-135a (miR-135a) down-modulates parameters of cancer progression and its expression is decreased in metastatic breast cancers (as compared to non-metastatic tumors) as well as in prostate tumors relative to normal tissue. These expression and activity patterns are opposite to those of the Estrogen-Related Receptor α (ERRα), an orphan member of the nuclear receptor family. Indeed high expression of ERRα correlates with poor prognosis in breast and prostate cancers, and the receptor promotes various traits of cancer aggressiveness including cell invasion. Here we show that miR-135a down-regulates the expression of ERRα through specific sequences of its 3’UTR. As a consequence miR-135a also reduces the expression of downstream targets of ERRα. miR-135a also decreases cell invasive potential in an ERRα-dependent manner. Our results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRα expression, resulting in increased cell invasion capacities.
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spelling pubmed-48819922016-06-10 miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα Tribollet, Violaine Barenton, Bruno Kroiss, Auriane Vincent, Séverine Zhang, Ling Forcet, Christelle Cerutti, Catherine Périan, Séverine Allioli, Nathalie Samarut, Jacques Vanacker, Jean-Marc PLoS One Research Article MicroRNA-135a (miR-135a) down-modulates parameters of cancer progression and its expression is decreased in metastatic breast cancers (as compared to non-metastatic tumors) as well as in prostate tumors relative to normal tissue. These expression and activity patterns are opposite to those of the Estrogen-Related Receptor α (ERRα), an orphan member of the nuclear receptor family. Indeed high expression of ERRα correlates with poor prognosis in breast and prostate cancers, and the receptor promotes various traits of cancer aggressiveness including cell invasion. Here we show that miR-135a down-regulates the expression of ERRα through specific sequences of its 3’UTR. As a consequence miR-135a also reduces the expression of downstream targets of ERRα. miR-135a also decreases cell invasive potential in an ERRα-dependent manner. Our results suggest that the decreased expression of miR-135a in metastatic tumors leads to elevated ERRα expression, resulting in increased cell invasion capacities. Public Library of Science 2016-05-26 /pmc/articles/PMC4881992/ /pubmed/27227989 http://dx.doi.org/10.1371/journal.pone.0156445 Text en © 2016 Tribollet et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Tribollet, Violaine
Barenton, Bruno
Kroiss, Auriane
Vincent, Séverine
Zhang, Ling
Forcet, Christelle
Cerutti, Catherine
Périan, Séverine
Allioli, Nathalie
Samarut, Jacques
Vanacker, Jean-Marc
miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα
title miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα
title_full miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα
title_fullStr miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα
title_full_unstemmed miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα
title_short miR-135a Inhibits the Invasion of Cancer Cells via Suppression of ERRα
title_sort mir-135a inhibits the invasion of cancer cells via suppression of errα
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881992/
https://www.ncbi.nlm.nih.gov/pubmed/27227989
http://dx.doi.org/10.1371/journal.pone.0156445
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