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Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target

Dopaminergic (DA) neurons in the midbrain provide rich, topographic innervation of the striatum and are central to learning and to generating actions. Despite the importance of this DA innervation, it remains unclear if and how DA neurons are specialized based on the location of their striatal targe...

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Autores principales: Parker, Nathan F., Cameron, Courtney M., Taliaferro, Joshua P., Lee, Junuk, Choi, Jung Yoon, Davidson, Thomas J., Daw, Nathaniel D., Witten, Ilana B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882228/
https://www.ncbi.nlm.nih.gov/pubmed/27110917
http://dx.doi.org/10.1038/nn.4287
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author Parker, Nathan F.
Cameron, Courtney M.
Taliaferro, Joshua P.
Lee, Junuk
Choi, Jung Yoon
Davidson, Thomas J.
Daw, Nathaniel D.
Witten, Ilana B.
author_facet Parker, Nathan F.
Cameron, Courtney M.
Taliaferro, Joshua P.
Lee, Junuk
Choi, Jung Yoon
Davidson, Thomas J.
Daw, Nathaniel D.
Witten, Ilana B.
author_sort Parker, Nathan F.
collection PubMed
description Dopaminergic (DA) neurons in the midbrain provide rich, topographic innervation of the striatum and are central to learning and to generating actions. Despite the importance of this DA innervation, it remains unclear if and how DA neurons are specialized based on the location of their striatal target. Thus, we sought to compare the function of subpopulations of DA neurons that target distinct striatal subregions in the context of an instrumental reversal learning task. We identified key differences in the encoding of reward and choice in dopamine terminals in dorsal versus ventral striatum: DA terminals in ventral striatum responded more strongly to reward consumption and reward-predicting cues, whereas DA terminals in dorsomedial striatum responded more strongly to contralateral choices. In both cases the terminals encoded a reward prediction error. Our results suggest that the DA modulation of the striatum is spatially organized to support the specialized function of the targeted subregion.
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spelling pubmed-48822282016-10-25 Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target Parker, Nathan F. Cameron, Courtney M. Taliaferro, Joshua P. Lee, Junuk Choi, Jung Yoon Davidson, Thomas J. Daw, Nathaniel D. Witten, Ilana B. Nat Neurosci Article Dopaminergic (DA) neurons in the midbrain provide rich, topographic innervation of the striatum and are central to learning and to generating actions. Despite the importance of this DA innervation, it remains unclear if and how DA neurons are specialized based on the location of their striatal target. Thus, we sought to compare the function of subpopulations of DA neurons that target distinct striatal subregions in the context of an instrumental reversal learning task. We identified key differences in the encoding of reward and choice in dopamine terminals in dorsal versus ventral striatum: DA terminals in ventral striatum responded more strongly to reward consumption and reward-predicting cues, whereas DA terminals in dorsomedial striatum responded more strongly to contralateral choices. In both cases the terminals encoded a reward prediction error. Our results suggest that the DA modulation of the striatum is spatially organized to support the specialized function of the targeted subregion. 2016-04-25 2016-06 /pmc/articles/PMC4882228/ /pubmed/27110917 http://dx.doi.org/10.1038/nn.4287 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Parker, Nathan F.
Cameron, Courtney M.
Taliaferro, Joshua P.
Lee, Junuk
Choi, Jung Yoon
Davidson, Thomas J.
Daw, Nathaniel D.
Witten, Ilana B.
Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target
title Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target
title_full Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target
title_fullStr Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target
title_full_unstemmed Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target
title_short Reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target
title_sort reward and choice encoding in terminals of midbrain dopamine neurons depends on striatal target
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882228/
https://www.ncbi.nlm.nih.gov/pubmed/27110917
http://dx.doi.org/10.1038/nn.4287
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