Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury

Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here, we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammato...

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Autores principales: Ueno, Masaki, Ueno-Nakamura, Yuka, Niehaus, Jesse, Popovich, Phillip G., Yoshida, Yutaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882232/
https://www.ncbi.nlm.nih.gov/pubmed/27089020
http://dx.doi.org/10.1038/nn.4289
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author Ueno, Masaki
Ueno-Nakamura, Yuka
Niehaus, Jesse
Popovich, Phillip G.
Yoshida, Yutaka
author_facet Ueno, Masaki
Ueno-Nakamura, Yuka
Niehaus, Jesse
Popovich, Phillip G.
Yoshida, Yutaka
author_sort Ueno, Masaki
collection PubMed
description Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here, we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.
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spelling pubmed-48822322016-10-18 Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury Ueno, Masaki Ueno-Nakamura, Yuka Niehaus, Jesse Popovich, Phillip G. Yoshida, Yutaka Nat Neurosci Article Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here, we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression. 2016-04-18 2016-06 /pmc/articles/PMC4882232/ /pubmed/27089020 http://dx.doi.org/10.1038/nn.4289 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ueno, Masaki
Ueno-Nakamura, Yuka
Niehaus, Jesse
Popovich, Phillip G.
Yoshida, Yutaka
Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury
title Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury
title_full Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury
title_fullStr Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury
title_full_unstemmed Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury
title_short Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury
title_sort silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882232/
https://www.ncbi.nlm.nih.gov/pubmed/27089020
http://dx.doi.org/10.1038/nn.4289
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